Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults
Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults
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DOI：
10.1016/j.vaccine.2009.01.136
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发表时间：
2009-04-21
期刊：
影响因子：
5.5
通讯作者：
Bleackley, R. Chris
中科院分区：
文献类型：
--
作者：
McElhaney, Janet E.;Ewen, Catherine;Bleackley, R. Chris
本研究比较了流感疫苗接种后血清抗体滴度和病毒刺激的外周血单个核细胞颗粒酶B（Grz B）水平。239名老年人中有12人随后发生实验室诊断的流感疾病（LDI），与无LDI的受试者相比，GrzB水平显著降低（p=0.004）。8例前一年患有LDI的受试者显示出对疫苗接种的GrzB反应增强（p = 0.02）。接种疫苗后的血清抗体滴度并不能区分那些发生LDI的老年人和那些没有发生LDI的老年人。这些结果表明，GrzB水平可以与抗体滴度相结合，以更有效地预测老年人的疫苗效力。(C)2009爱思唯尔有限公司版权所有。
This study Compared serum antibody titers and granzyme B (GrzB) levels in virus-stimulated peripheral blood mononuclear cells following influenza vaccination. Twelve of 239 older adults who subsequently developed laboratory-diagnosed influenza illness (LDI) had significantly lower GrzB levels compared to subjects without LDI (p=0.004). Eight subjects with LDI in the previous year showed an enhanced GrzB response to vaccination (p = 0.02). Serum antibody titers following vaccination did not distinguish those older adults who developed LDI from those who did not. These results suggest that GrzB levels could be combined with antibody titers to more effectively predict vaccine efficacy in older adults. (C) 2009 Elsevier Ltd. All rights reserved.