Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures.
Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures.
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DOI：
10.3389/fcell.2020.628114
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发表时间：
2020
影响因子：
5.5
通讯作者：
Lei M
中科院分区：
文献类型：
--
作者：
Qiu W;Gu PR;Chuong CM;Lei M
囊肿是一种封闭的囊状结构，囊壁包裹着某些内容物，通常包括空气、液体、脂质、粘液或角蛋白。囊肿细胞可以保持多能性，以再生复杂的组织结构，或分化。由于遗传问题、胚胎发育错误、细胞缺陷、慢性炎症、感染、管道堵塞、寄生虫和损伤，囊肿可以在皮肤内外形成。多种类型的皮肤囊肿具有不同的细胞起源，其共同结构包括囊肿外壁吞噬分化的基底上层和角蛋白。皮肤囊肿常作为病理诊断的标志。大的或表面的皮肤囊肿影响患者的外观，并可能引起邻近组织的功能障碍或伴随疾病。皮肤囊肿的形成是皮肤上皮和附属物退化的结果，保留了多能性的某些特征。令人惊讶的是，最近的类器官培养显示囊肿形态的形成是一种向形态发生可能性过渡的状态。这些结果表明，如果我们能够更多地了解控制囊肿形成中上游和下游细胞事件的分子电路，我们可能能够设计干细胞培养以实现我们希望实现的表型。对于患者的病理情况，我们推测也有可能引导囊肿分化或去分化，以产生更类似于正常结构并与皮肤稳态相容的结构。
A cyst is a closed sac-like structure in which cyst walls wrap certain contents typically including air, fluid, lipid, mucous, or keratin. Cyst cells can retain multipotency to regenerate complex tissue architectures, or to differentiate. Cysts can form in and outside the skin due to genetic problems, errors in embryonic development, cellular defects, chronic inflammation, infections, blockages of ducts, parasites, and injuries. Multiple types of skin cysts have been identified with different cellular origins, with a common structure including the outside cyst wall engulfs differentiated suprabasal layers and keratins. The skin cyst is usually used as a sign in pathological diagnosis. Large or surfaced skin cysts affect patients’ appearance and may cause the dysfunction or accompanying diseases of adjacent tissues. Skin cysts form as a result of the degradation of skin epithelium and appendages, retaining certain characteristics of multipotency. Surprisingly, recent organoid cultures show the formation of cyst configuration as a transient state toward more morphogenetic possibility. These results suggest, if we can learn more about the molecular circuits controlling upstream and downstream cellular events in cyst formation, we may be able to engineer stem cell cultures toward the phenotypes we wish to achieve. For pathological conditions in patients, we speculate it may also be possible to guide the cyst to differentiate or de-differentiate to generate structures more akin to normal architecture and compatible with skin homeostasis.
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影响因子：
23.9
作者：
Adam RC;Yang H;Ge Y;Lien WH;Wang P;Zhao Y;Polak L;Levorse J;Baksh SC;Zheng D;Fuchs E
通讯作者：
Fuchs E
在没有刺猬信号的情况下，头发发育异常和明显的卵泡转化向乳腺。
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作者：
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通讯作者：
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影响因子：
2.6
作者：
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通讯作者：
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作者：
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通讯作者：
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