Formation of square lamellae by self-assembly of long-chain bolaphospholipids in water
Formation of square lamellae by self-assembly of long-chain bolaphospholipids in water
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DOI：
10.1039/b923066a
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发表时间：
2010-03
期刊：
影响因子：
3.4
通讯作者：
A. Meister;Simon Drescher;G. Karlsson;G. Hause;U. Baumeister;G. Hempel;V. Garamus;B. Dobner;A. Blume
中科院分区：
文献类型：
--
作者：
A. Meister;Simon Drescher;G. Karlsson;G. Hause;U. Baumeister;G. Hempel;V. Garamus;B. Dobner;A. Blume
对称单链聚亚甲基-1，ω-双（磷酸胆碱）（PC-C34-PC）具有34个碳原子的链长和两个极性磷酸胆碱头基，当将其放入水中时，其自组装过程完全由长烷基链的疏水相互作用驱动。该过程导致螺旋纳米纤维的致密网络的形成和水凝胶的形成（Meister等人，J. Phys. Chem. B，2008，112，4506）。相比之下，单链bolalipids tetra-和hexatriacontane-1，ω-diyl-bis[2-（dimethylammonio）ethyl phosphate]（Me 2 PE-Cn-Me 2 PE，n = 34，36）和部分氘化类似物Me 2 PE-C11-（CD 2）12-C11-Me 2 PE（dMe 2 PE-C34-Me 2 PE）形成不同类型的稳定聚集体。在第一步中，这些长链bolalipids在室温下在水中的自组装导致形成致密的纳米纤维网络，其最终形成水凝胶。在一天之内，纳米纤维转变成方形薄片，其生长到约100 nm的边长。纳米纤维连接到正方形的一个或两个（相对）角，导致风筝状结构的外观。一周后，所有的纤维都转化成方形薄片，这些薄片明显堆叠并形成凝胶饼。在几周内，通过脱水收缩，即排出水，形成更致密的饼。
The self-assembly process of the symmetric single-chain polymethylene-1,ω-bis(phosphocholine) (PC-C34-PC) with a chain length of 34 carbon atoms and two polar phosphocholine headgroups when put into water is exclusively driven by hydrophobic interactions of the long alkyl chains. This process leads to the formation of a dense network of helical nanofibers and the formation of a hydrogel (Meister et al. J. Phys. Chem. B, 2008, 112, 4506). In contrast, the single-chain bolalipids tetra- and hexatriacontane-1,ω-diyl-bis[2-(dimethylammonio)ethylphosphate] (Me2PE-Cn-Me2PE, n = 34, 36) and the partly deuterated analogue Me2PE-C11-(CD2)12-C11-Me2PE (dMe2PE-C34-Me2PE) form a different type of stable aggregate. In a first step, the self-assembly of these long-chain bolalipids in water at room temperature leads to the formation of a dense network of nanofibers which eventually form a hydrogel. Within one day, the nanofibers transform into square lamellae that grow up to an edge length of about 100 nm. Nanofibers are linked to one or two (opposite) corners of the squares leading to the appearance of a kite-like structure. After one week, all fibers have been transformed into square lamellae which are apparently stacked and form a gel cake. Within several weeks, a more compact cake is formed by syneresis, i.e. the expulsion of water.