β-Endorphin as a potent analgesic by intravenous injection
β-Endorphin as a potent analgesic by intravenous injection
复制标题
β-内啡肽作为静脉注射的强效镇痛药
作者：
L. Tseng;H. Loh;Choh Hao Li
从骆驼脑垂体腺提取的具有显著阿片活性的untriakonapapeptide 1的氨基酸序列与β-Lipotroins 2，3的31个氨基酸的羧基末端相同。这种被命名为β-Endphin的多肽是最近合成的4，当直接进入大脑时，它被发现在摩尔基础上比吗啡强得多，它的作用被纳洛酮阻断。其他与β-促脂激素相关的多肽在体外也被证明具有阿片样活性6-9。我们报道了静脉注射β-内啡肽的镇痛作用。
AN untriakontapeptide1 with significant opiate activity from camel pituitary glands was shown to have an amino acid sequence identical to the carboxyl-terminal 31 amino acids of β-lipotropins2,3. The peptide, designated as β-endorphin, has recently been synthesised4, and when administered directly into the brain, it was found5 to be considerably more potent than morphine in molar basis, and its actions were blocked by naloxone. Other peptides related to β-lipotropins have also been shown to possess in vitro opiate-like activity6–9. We report here the analgesic effects of β-endorphin when it is injected intravenously.