Choroidal Thickness in Polypoidal Choroidal Vasculopathy and Exudative Age-related Macular Degeneration
Choroidal Thickness in Polypoidal Choroidal Vasculopathy and Exudative Age-related Macular Degeneration
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DOI：
10.1016/j.ophtha.2010.09.012
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发表时间：
2011-05-01
期刊：
影响因子：
13.7
通讯作者：
Kim, Yun Taek
中科院分区：
文献类型：
--
作者：
Chung, Song Ee;Kang, Se Woong;Kim, Yun Taek
目的：比较息肉状脉络膜血管病变（PCV）和年龄相关性黄斑变性（AMD）患者的脉络膜厚度。设计：观察性比较病例系列。参与者：PCV患者25只眼，PCV患者14只眼，渗出性AMD患者30只眼，早期AMD患者17只眼，年龄匹配的正常受试者20只眼。使用增强深度成像光学相干断层扫描测量脉络膜厚度。通过测量从布鲁赫膜到最内层巩膜层的垂直距离来分析每只眼睛的中心凹下脉络膜厚度。所有眼睛的鼻侧、上级、颞侧和下侧脉络膜厚度（距中心凹中心1500 μ m）也进行了评估。主要结果测量：各组的脉络膜厚度。是说PCV患眼和未受累眼的中心凹下脉络膜厚度（+/-标准差）分别为438.3 +/- 87.8 μ m和372.9 +/-87.8 μ m。112.0 μ m，显著大于年龄匹配的正常受试者的眼睛（224.8 ± 52.9 μ m）（分别为P < 0.001和P = 0.003）。渗出型AMD（171.2 ± 38.5 μ m）和早期AMD（177.4 ± 49.7 μ m）的黄斑中心凹下脉络膜厚度较年龄匹配的正常人薄（分别为P = 0.004和P = 0.078）。其他4个点的脉络膜厚度表现出类似的趋势。结论：这项研究表明，在PCV的眼睛脉络膜增厚，与脉络膜变薄的AMD的眼睛。这些研究结果表明参与PCV从那些渗出性AMD.Financial披露（S）的不同致病机制：作者（S）在本文中讨论的任何材料没有专有或商业利益。Ophthalmology 2011; 118：840-845（C）2011，美国眼科学会。
Purpose: To compare choroidal thickness between eyes with polypoidal choroidal vasculopathy (PCV) and eyes with age-related macular degeneration (AMD).Design: Observational, comparative case series.Participants: Twenty-five eyes with PCV, 14 uninvolved fellow eyes with PCV, 30 eyes with exudative AMD, 17 eyes with early AMD, and 20 eyes of age-matched normal subjects.Methods: Choroidal thickness was measured using enhanced-depth imaging optical coherence tomography. Subfoveal choroidal thickness in each eye was analyzed by measurement of the vertical distance from the Bruch's membrane to the innermost scleral layer. Nasal, superior, temporal, and inferior choroidal thicknesses, 1500 mu m apart from the foveal center, were also evaluated in all eyes.Main Outcome Measures: Choroidal thickness in each group.Results: Mean (+/- standard deviation) subfoveal choroidal thickness in eyes with PCV and in their uninvolved fellow eyes was 438.3 +/- 87.8 mu m and 372.9 +/- 112.0 mu m, respectively, which was significantly greater than in eyes of age-matched normal subjects (224.8 +/- 52.9 mu m) (P < 0.001 and P = 0.003, respectively). Subfoveal choroidal thickness of eyes with exudative AMD (171.2 +/- 38.5 mu m) and eyes with early AMD (177.4 +/- 49.7 mu m) was thinner than that of age-matched normal subjects (P = 0.004 and P = 0.078, respectively). Choroidal thickness at each of the other 4 points showed a similar tendency.Conclusions: This study demonstrates thickening of choroid in the eyes with PCV, in contrast with choroidal thinning observed in eyes with AMD. These findings suggest involvement of different pathogenic mechanisms in PCV from those in exudative AMD.Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2011; 118: 840-845 (C) 2011 by the American Academy of Ophthalmology.