Genomic analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains isolated in Malaysia
Genomic analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains isolated in Malaysia
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对马来西亚分离的严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 株的基因组分析
DOI：
10.36877/pmmb.a0000093
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Learn‐Han Lee
中科院分区：
文献类型：
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作者：
Hooi‐Leng Ser;Loh Teng;Jodi Woan‐Fei Law;V. Letchumanan;N. A. Mutalib;Learn‐Han Lee
目前的研究使用在马来西亚分离的人类 SARS-CoV-2 的七个完整基因组（从 GISAID 检索）进行系统发育树构建，表明与来自亚洲、欧洲和美国的其他代表性菌株相比，这些菌株形成了四个不同的进化枝。有鉴于此，在马来西亚分离的这些菌株的基因组序列表明，该国目前存在不止一种“类型”的菌株。与流行病学和实验研究相辅相成，这些发现可以更好地了解马来西亚某些类型的流行情况，并可以进一步深入研究这些菌株的毒力和致病机制，这对于加快有效治疗方案的开发尤为关键。
Using seven complete genomes of human SARS-CoV-2 (retrieved from GISAID) isolated in Malaysia forphylogenetic tree construction, the current study showed that these strains formed four distinct clades when compared with other representative strains from Asia, Europe and US. In light of that, the genome sequences of these strains isolated in Malaysia suggested that there is currently more than one “type” of strain within the country. Complementing with epidemiological and experimental studies, these findings allow better understanding the prevalence of certain types in Malaysia and permits further in-depth studies on the virulence and pathogenic mechanisms of these strains which is particularly critical to speed up the development of effective treatment regime.