Deregulated TGF-β signaling in leukemogenesis
Deregulated TGF-β signaling in leukemogenesis
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DOI：
10.1038/sj.onc.1208923
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发表时间：
2005-08-29
期刊：
影响因子：
8
通讯作者：
Pandolfi, PP
中科院分区：
文献类型：
--
作者：
Lin, HK;Bergmann, S;Pandolfi, PP
细胞内稳态受到调节细胞增殖和细胞死亡的各种途径的严格控制。打破这种平衡通常与癌症的发展有关。转化生长因子-β（TGF-β）途径通过调节细胞生长抑制、细胞衰老、分化和凋亡在细胞内稳态中起重要作用。已知TGF-β信号失调与多种人类癌症有关，包括结肠癌、胰腺癌、乳腺癌和前列腺癌。虽然TGF-β是造血的有效负调节剂，但异常TGF-β信号传导在白血病发生中的作用仍然很大程度上未知。最近，有证据表明，白血病，特别是急性早幼粒细胞白血病（APL）的TGF-β信号失调，已经开始出现。在这篇综述中，我们总结了目前的进展，了解异常的TGF-β信号可能参与白血病发生的分子机制。
Cellular homeostasis is tightly controlled by the various pathways that regulate cell proliferation and cell death. Breaking this balance is often associated with cancer development. The transforming growth factor-beta (TGF-beta) pathway plays an important role in cellular homeostasis by regulating cell growth inhibition, cellular senescence, differentiation and apoptosis. Deregulated TGF-beta signaling is known to be involved in a variety of human cancers, including those of the colon, pancreas, breast and prostate. While TGF-beta is a potent negative regulator of hematopoiesis, the role of aberrant TGF-beta signaling in leukemogenesis remains largely unknown. Recently, evidence demonstrating deregulated TGF-beta signaling in leukemogenesis, particularly in acute promyelocytic leukemia (APL), has started to emerge. In this review, we summarize the current progress towards the understanding of the molecular mechanisms by which aberrant TGF-beta signaling may participate in leukemogenesis.