The mouse pink-eyed dilution allele of the P-gene greatly inhibits eumelanin but not pheomelanin synthesis
The mouse pink-eyed dilution allele of the P-gene greatly inhibits eumelanin but not pheomelanin synthesis
复制标题
DOI：
10.1111/j.1755-148x.2010.00783.x
复制
发表时间：
2011-02-01
影响因子：
4.3
通讯作者：
Wakamatsu, Kazumasa
中科院分区：
文献类型：
--
作者：
Hirobe, Tomohisa;Ito, Shosuke;Wakamatsu, Kazumasa
已知小鼠红眼稀释（p）基因座控制黑素细胞中真黑素合成、黑素体形态和酪氨酸酶活性。然而，尚未完全确定突变等位基因p是否影响褐黑素合成。通过对F（2）代5周龄小鼠背毛的化学分析，研究了p等位基因对真黑素和非黑素合成的影响（黑色，粉眼黑色，隐性黄色，粉眼隐性黄色，agglomerate，C57 BL/10 JHir（B10）-同系粉眼黑小鼠（B10-p/p）与隐性黄小鼠（B10-Mc 1 re/Mc 1 re）或粉眼黑小鼠（B10-A/A）之间的遗传差异。与相应的P/-小鼠相比，粉眼黑小鼠和粉眼无色素小鼠中的真黑素含量显著降低（> 20倍），而粉眼黑小鼠、粉眼隐性黄小鼠或粉眼无色素小鼠中的褐黑素含量没有降低。这些结果表明，粉红色眼睛的稀释等位基因大大抑制真黑素的合成，但不是褐黑素的合成。
P>The mouse pink-eyed dilution (p) locus is known to control eumelanin synthesis, melanosome morphology, and tyrosinase activity in melanocytes. However, it has not been fully determined whether the mutant allele, p affects pheomelanin synthesis. Effects of the p allele on eumelanin and phemelanin synthesis were investigated by chemical analysis of dorsal hairs of 5-week-old mice obtained from the F(2) generations (black, pink-eyed black, recessive yellow, pink-eyed recessive yellow, agouti, and pink-eyed agouti) between C57BL/10JHir (B10)-congenic pink-eyed black mice (B10-p/p) and recessive yellow (B10-Mc1re/Mc1re) or agouti (B10-A/A) mice. The eumelanin content was dramatically (> 20-fold) decreased in pink-eyed black and pink-eyed agouti mice, whereas the pheomelanin content did not decrease in pink-eyed black, pink-eyed recessive yellow, or pink-eyed agouti mice compared to the corresponding P/- mice. These results suggest that the pink-eyed dilution allele greatly inhibits eumelanin synthesis, but not pheomelanin synthesis.