Graft Weight/Recipient Weight Ratio: How Well Does It Predict Outcome After Partial Liver Transplants?
Graft Weight/Recipient Weight Ratio: How Well Does It Predict Outcome After Partial Liver Transplants?
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DOI：
10.1002/lt.21846
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发表时间：
2009-09-01
影响因子：
4.6
通讯作者：
Humar, Abhinav
中科院分区：
文献类型：
--
作者：
Hill, Mark J.;Hughes, Michael;Humar, Abhinav
移植物重量/受体重量（GW/RW）比值< 0.8%的部分移植肝受体被认为具有较高的术后并发症发生率，包括小体积综合征（SFSS）。我们分析了一组这样的受体，并将GW/RW < 0.8%的受体与GW/RW的受体进行了比较！百分之零点八。在1999年至2008年期间，107例成人患者接受了部分移植肝移植：76例来自活体供体[活体肝移植（LDLT）]，31例来自死亡供体[劈离式肝移植（LLT）]。其中，22例GW/RW < 0.8%（12例LDLT和10例LDLT），85例GW/RW！0.8%（64例LDLT和21例SILT）。基线人口统计学和中位随访时间相似。3例GW/RW < 0.8%（13.6%）和8例GW/RW >= 0.8%（9.4%; P =无显著性）的受者发生SFSS。两组的其他早期并发症相似。13例受者行脾动脉阻断入流改良，其中GW/RW < 0.8%者7例，GW/RW <0.8%者6例。移植后1年的移植物存活率没有差异（91% vs 92%; P =不显著）。总之，GW/RW似乎不是部分肝移植术后结局的唯一决定因素。使用流入道改良等技术可能有助于防止较小移植物出现的一些问题。肝移植15：1056-1062，2009。(C)2009年AASLD。
Partial graft liver recipients with graft weight/recipient weight (GW/RW) ratios < 0.8% are thought to have a higher incidence of postoperative complications, including small-for-size syndrome (SFSS). We analyzed a cohort of such recipients and compared those with GW/RW < 0.8% to those with GW/RW ! 0.8%. Between 1999 and 2008, 107 adult patients underwent partial graft liver transplants: 76 from live donors [living donor liver transplantation (LDLT)] and 31 from deceased donors [split liver transplantation (SLT)]. Of these, 22 had GW/RW < 0.8% (12 with LDLT and 10 with SLT), and 85 had GW/RW ! 0.8% (64 with LDLT and 21 with SILT). The baseline demographics and median length of follow-up were similar. SFSS developed in 3 recipients with GW/RW < 0.8% (13.6%) and in 8 recipients with GW/RW >= 0.8% (9.4%; P = not significant). Other early complications were similar between the 2 groups. Inflow modification with splenic artery occlusion was performed in 13 recipients: 7 with GW/RW < 0.8% and 6 with GW/RW a 0.8%. Graft survival at 1 year post-transplant did not differ (91% versus 92%; P = not significant). In conclusion, GW/RW did not appear to be the only determinant of outcome after partial liver transplantation. Using techniques such as inflow modification may help to prevent some of the problems seen with smaller grafts. Liver Transpl 15:1056-1062, 2009. (C) 2009 AASLD.