Incidence of acute kidney injury and its association with mortality in patients with COVID-19: a meta-analysis
Incidence of acute kidney injury and its association with mortality in patients with COVID-19: a meta-analysis
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DOI：
10.1136/jim-2020-001407
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发表时间：
2020-10-01
影响因子：
2.6
通讯作者：
Ghahramani, Nasrollah
中科院分区：
文献类型：
--
作者：
Hansrivijit, Panupong;Qian, Chenchen;Ghahramani, Nasrollah
急性肾损伤（AKI）是COVID-19的并发症。然而，在不同的研究中，COVID-19的AKI发生率各不相同。因此，我们旨在通过荟萃分析评估COVID-19患者AKI的总发病率及其与死亡率的关系。我们检索Ovid MEDLINE、EMBASE和Cochrane图书馆，寻找符合条件的无语言限制的报告COVID-19患者临床特征的出版物。报告AKI的发病率和死亡率。meta回归用于描述结果之间的关联。从26项研究（n=5497）中，COVID-19患者AKI的合并发病率为8.4% (95% CI 6.0%至11.7%)，肾脏替代治疗的合并发病率为3.6% （95% CI 1.8%至7.1%）。重症患者AKI发生率（19.9%）高于住院患者（7.3%）。AKI死亡率的合并估计优势比为13.33 （95% CI 4.05 ~ 43.91）。未发现潜在的发表偏倚。通过meta回归分析，调整年龄和性别后，AKI发病率与死亡率呈正相关（Q=26.18; p=0.02）。此外，年龄(p
Acute kidney injury (AKI) is a complication of COVID-19. However, the incidence of AKI in COVID-19 varies among studies. Thus, we aimed to evaluate the pooled incidence of AKI and its association with mortality in patients with COVID-19 using a meta-analysis. We search Ovid MEDLINE, EMBASE, and the Cochrane Library for eligible publications reporting the clinical characteristics of patients with COVID-19 without language restriction. Incidence of AKI and mortality were reported. Meta-regression was used to describe the association between outcomes. From 26 studies (n=5497), the pooled incidence of AKI in patients with COVID-19 was 8.4% (95% CI 6.0% to 11.7%) with a pooled incidence of renal replacement therapy of 3.6% (95% CI 1.8% to 7.1%). The incidence of AKI was higher in critically ill patients (19.9%) compared with hospitalized patients (7.3%). The pooled estimated odds ratio for mortality from AKI was 13.33 (95% CI 4.05 to 43.91). No potential publication bias was detected. By using meta-regression analyses, the incidence of AKI was positively associated with mortality after adjusted for age and sex (Q=26.18; p=0.02). Moreover, age (p