Controlling enzyme reactions by supramolecular protection and deprotection of oligosaccharide substrates
Controlling enzyme reactions by supramolecular protection and deprotection of oligosaccharide substrates
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通过寡糖底物的超分子保护和脱保护来控制酶反应
DOI：
10.1039/d2cc03239b
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发表时间：
2022
影响因子：
4.9
通讯作者：
Zhao, Yan
中科院分区：
文献类型：
--
作者：
Zangiabadi, Milad;Zhao, Yan
保护/脱保护是复杂有机分子全合成中的一种强有力的策略，但类似的工具在酶促反应中几乎不存在。在这里，我们报告超分子保护受体，竞争优势的酶结合的寡糖。强结合抑制酶促反应，并且加入更强的受体配体释放底物。这些受体可用于控制来自相同底物/酶混合物的产物，并可逆地调节酶促反应。
Protection/deprotection is a powerful strategy in the total synthesis of complex organic molecules but similar tools are nearly absent in enzymatic reactions. We here report supramolecular protective receptors that outcompete an enzyme in the binding of oligosaccharides. The strong binding inhibits the enzymatic reaction and addition of an even stronger ligand for the receptor releases the substrate. These receptors could be used to control products from the same substrate/enzyme mixture and regulate enzymatic reactions reversibly.