Inflammatory bowel disease of primary sclerosing cholangitis: A distinct entity?
Inflammatory bowel disease of primary sclerosing cholangitis: A distinct entity?
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DOI：
10.3748/wjg.v20.i12.3245
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发表时间：
2014-03-28
影响因子：
4.3
通讯作者：
Joh, Takashi
中科院分区：
文献类型：
--
作者：
Nakazawa, Takahiro;Naitoh, Itaru;Joh, Takashi
本文综述了原发性硬化性胆管炎（PSC）伴发炎症性肠病（IBD）的特征性表现及其在诊断硬化性胆管炎中的作用。PSC是一种以特发性纤维性梗阻为特征的慢性炎症性疾病，通常与IBD相关。IBD相关PSC（PSC-IBD）显示全结肠炎、轻度症状和结直肠恶性肿瘤的发生率增加。虽然全结肠炎的发病率增加是一个特征性的发现，一些病例被内镜诊断为右侧溃疡性结肠炎。病理学研究表明，炎症发生在右结肠比左结肠更频繁。直肠保留和回肠炎的发生率应在未来的研究中基于相同的定义进行调查。免疫球蛋白G4相关性硬化性胆管炎（IgG 4-SC）的胆管造影表现与PSC相似。IBD和IgG 4-SC之间的罕见关联以及PSC-IBD的独特特征是区分PSC和IgG 4-SC的有用发现。（C）2014年百世登出版集团有限公司，有限公司All rights reserved.
This is a review of the characteristic findings of inflammatory bowel disease (IBD) associated with primary sclerosing cholangitis (PSC) and their usefulness in the diagnosis of sclerosing cholangitis. PSC is a chronic inflammatory disease characterized by idiopathic fibrous obstruction and is frequently associated with IBD. IBD-associated with PSC (PSC-IBD) shows an increased incidence of pancolitis, mild symptoms, and colorectal malignancy. Although an increased incidence of pancolitis is a characteristic finding, some cases are endoscopically diagnosed as right-sided ulcerative colitis. Pathological studies have revealed that inflammation occurs more frequently in the right colon than the left colon. The frequency of rectal sparing and backwash ileitis should be investigated in a future study based on the same definition. The cholangiographic findings of immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) are similar to those of PSC. The rare association between IBD and IgG4-SC and the unique characteristics of PSC- IBD are useful findings for distinguishing PSC from IgG4-SC. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.