The effects of increasing ocular surface stimulation on blinking and sensation.
The effects of increasing ocular surface stimulation on blinking and sensation.
复制标题
增加眼表刺激对眨眼和感觉的影响。
DOI：
10.1167/iovs.13-13780
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发表时间：
2014
影响因子：
4.4
通讯作者：
Simpson,Trefford
中科院分区：
文献类型：
--
作者：
Wu,Ziwei;Begley,CarolynG;Situ,Ping;Simpson,Trefford
目的：本研究的目的是确定增加眼表刺激如何影响眨眼和感觉，同时控制任务注意力。方法：10名健康受试者集中精力完成一项任务，同时一个定制的气动装置产生朝向中央角膜的气流。六个流速（FR），随机提出了三次，每个和受试者使用视觉模拟量表，以记录他们的感觉反应。同时记录每项试验的眨眼间间隔（IBI）和FR，并确定IBI、感觉反应和相应的FR。计算每名受试者与IBI统计学显著降低相关的FR，即眨眼增加阈值（BIT）。结果：IBI的平均值和SD均随刺激增加而降低，从基线时的5.69±3.96秒降至最大刺激时的1.02±0.37秒。平均BIT为129±20 mL/min，IBI为2.33±1.10 s（排列检验，P< 0.001）。对数转换后，每个受试者的FR增加和IBI减少之间存在显著的线性函数关系（Pearson's r≤-0.859，P< 0.05）。IBI与水感、不适和冷却等级高度相关（Pearson r≤-0.606，P< 0.001）。在健康受试者中，表面刺激增加与眨眼之间存在剂量反应样关系，可能是为了保护眼表。眨眼反应与眼表感觉高度相关，考虑到它们的共同起源，这并不奇怪。BIT是一种新的指标，可以为干眼症或其他疾病的研究提供额外的终点。
Purpose.: The purpose of this study was to determine how increasing ocular surface stimulation affected blinking and sensation, while controlling task concentration.Methods.: Ten healthy subjects concentrated on a task while a custom pneumatic device generated air flow toward the central cornea. Six flow rates (FRs) were randomly presented three times each and subjects used visual analog scales to record their sensory responses. The interblink interval (IBI) and the FR were recorded simultaneously and the IBI, sensory response, and corresponding FR were determined for each trial. The FR associated with a statistically significant decrease in IBI, the blink increase threshold (BIT), was calculated for each subject.Results.: Both the mean and SD of IBI were decreased with increasing stimulation, from 5.69±3.96 seconds at baseline to 1.02±0.37 seconds at maximum stimulation. The average BIT was 129±20 mL/min flow rate with an IBI of 2.33±1.10 seconds (permutation test, P< 0.001). After log transformation, there was a significant linear function between increasing FR and decreasing IBI within each subject (Pearson's r≤− 0.859, P< 0.05). The IBI was highly correlated with wateriness, discomfort, and cooling ratings (Pearson's r≤− 0.606, P< 0.001).Conclusions.: There was a dose-response–like relationship between increased surface stimulation and blinking in healthy subjects, presumably for protection of the ocular surface. The blink response was highly correlated with ocular surface sensation, which is not surprising given their common origins. The BIT, a novel metric, may provide an additional end point for studies on dry eye or other conditions.