Decreased Plasma β-Amyloid in the Alzheimer's Disease APP A673T Variant Carriers
Decreased Plasma β-Amyloid in the Alzheimer's Disease APP A673T Variant Carriers
复制标题
DOI：
10.1002/ana.24969
复制
发表时间：
2017-07-01
影响因子：
11.2
通讯作者：
Hiltunen, Mikko
中科院分区：
文献类型：
--
作者：
Martiskainen, Henna;Herukka, Sanna-Kaisa;Hiltunen, Mikko
我们研究了阿尔茨海默病(AD)相关罕见变异APP A673T和ABCA7 rs200538373-C与以人群为基础的健康中老年男性队列中β-淀粉样蛋白(Aβ)水平以及代谢和心血管健康参数的相关性。保护性APP A673T变异携带者的血浆Aβ40和Aβ42水平较对照组和ABCA7 rs200538373-C携带者平均低28%。这是第一个显示APP A673T携带者血浆中Aβ水平降低的报告，从而提供了证据，表明一生中较低的Aβ水平可能对AD具有保护作用。
We investigated the association of Alzheimer's disease (AD)-related rare variants APP A673T and ABCA7 rs200538373-C with the levels of beta-amyloid (A beta) and parameters of metabolic and cardiovascular health in a population-based cohort of healthy middle-aged and elderly men. Carriers of protective APP A673T variant had, on average, 28% lower levels of A beta 40 and A beta 42 in plasma as compared to the controls and the carriers of ABCA7 rs200538373-C. This is the first report to show decreased A beta levels in plasma in APP A673T carriers and thus provides evidence that lower A beta levels throughout life may be protective against AD.