Anemia after orchiectomy
Anemia after orchiectomy
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DOI：
10.1002/(sici)1096-8652(199811)59:3
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发表时间：
1998-11-01
影响因子：
12.8
通讯作者：
Hoagland, HC
中科院分区：
文献类型：
--
作者：
Fonseca, R;Rajkumar, SV;Hoagland, HC
双侧睾丸切除术后睾酮分泌减少可能导致男性正常红细胞性贫血。我们试图确定睾丸切除术对血红蛋白浓度的影响。患者于1993年和1994年在马约诊所接受评估，并因前列腺癌接受双侧睾丸切除术。所有患者均由一名泌尿科医生就诊。如果患者的术前全血细胞计数和血清肌酐水平正常，如果他们没有疾病进展（前列腺特异性抗原水平抑制，审查时没有临床进展的证据），如果他们在随访期间血清肌酐水平和平均红细胞体积正常，则将其纳入研究。术前及术后至少1次（>90天）测定全血细胞计数、前列腺特异性抗原（PSA）及血清肌酐（Cr）水平。64名患者被纳入分析（中位年龄68岁），睾丸切除术后血红蛋白浓度的中位下降为1.2 g/dL。通过配对组t检验和Kruskal-Wallis检验，睾丸切除术前的血红蛋白浓度与所有研究时间间隔的术后值相比存在统计学显著差异。睾丸切除术后血红蛋白浓度在临床上和统计学上显著降低。了解这一现象可以避免对双侧睾丸切除术后的正常红细胞性贫血患者进行不必要的诊断性检查。(C)1998 Wiley-Liss，Inc.
The decrease in testosterone production associated with bilateral orchiectomy may result in normocytic anemia in men. We sought to determine the effect of orchiectomy on hemoglobin concentration. Patients were evaluated at the Mayo Clinic in 1993 and 1994 and underwent bilateral orchiectomy for prostate carcinoma. All patients were seen by one of the staff urologists. Patients were included if they had a normal preoperative complete blood cell count and serum levels of creatinine, if they remained without disease progression (suppressed prostate-specific antigen level and no evidence of clinical progression on review), and if they had normal serum levels of creatinine and mean corpuscular volume during the follow-up period. The patients could have no other cause of anemia, The complete blood cell count, prostate-specific antigen level, and serum level of creatinine were determined preoperatively and at least once (>90 days) after orchiectomy. Sixty-four patients were included in the analysis (median age, 68 years), The median decrease in hemoglobin concentration was 1.2 g/dL after orchiectomy. There was a statistically significant difference in the hemoglobin concentration before orchiectomy compared with postoperative values at all the intervals studied, both by the paired group t-test and the Kruskal-Wallis test. There is a clinically and statistically significant decrease in hemoglobin concentration after orchiectomy. Knowledge of this phenomenon may prevent unnecessary diagnostic work-up in men with normocytic anemia after bilateral orchiectomy. (C) 1998 Wiley-Liss, Inc.