Sleep state, cardiorespiratory and electrocortical activity in infants with transposition of great vessels.
Sleep state, cardiorespiratory and electrocortical activity in infants with transposition of great vessels.
复制标题
大血管转位婴儿的睡眠状态、心肺和皮层电活动。
DOI：
10.1055/s-2007-973694
复制
发表时间：
1997
期刊：
影响因子：
1.4
通讯作者：
Schulze,KF
中科院分区：
文献类型：
--
作者：
Sahni,R;Schulze,KF
目的睡眠状态和睡眠期间的生理变化可能有助于评估大脑功能。我们假设患有大血管转位（TGV）的婴儿在异碳低氧血症条件下表现出可识别的睡眠状态。此外，我们推测低氧血症的早期纠正可能导致安静和活跃睡眠的生理特征发生显著变化。方法对5例足月TCV患儿进行术前、术后连续6小时的心肺和皮层电记录，同时进行分分钟的行为睡眠状态分配。对睡眠状态的数据进行排序，并计算每种状态的睡眠时间百分比。测量状态相关变量，即心率（HR）、心率变异性（HRSD）、呼吸频率(f)、呼吸频率变异性（fSD）以及静睡眠和活跃睡眠期间脑电图的频谱特性进行比较。结果在术前（平均o2饱和度= 80.9±2.8）和术后（平均o2饱和度= 92.8±0.5）两阶段，所有婴儿在安静睡眠和主动睡眠的状态相关变量均存在显著差异。与术前比较，术后安静睡眠时HR、HRSD较低，脑电图功率较大；活跃睡眠时，HR、HRSD和fSD降低，脑电图功率增加。此外，术后安静睡眠的百分比增加，活跃睡眠的百分比减少。结论在异碳低氧血症条件下，TCV血管患儿表现出明显可识别的睡眠状态。低氧血症的纠正与安静和活跃睡眠期间状态相关变量的显著变化有关。
ObjectivesSleep states and physiological changes during sleep may be useful in assessing brain function. We hypothesized that infants with transposition of great vessels (TGV) exhibit recognizable states of sleep under conditions of isocapnic hypoxemia. Also, we speculated that early correction of hypoxemia may result in significant changes in the physiological characteristics of quiet and active sleep.MethodsSix-hour continuous cardiorespiratory and electrocortical recordings were performed in five term infants with TCV, pre-and postoperatively along with simultaneous minute by minute behavioral sleep state assignment. Data were sorted for sleep states and percent sleep time for each state was computed. Measurements of state-dependent variables, ie, heart rate (HR), heart rate variability (HRSD), respiratory frequency (f), variability in respiratory frequency (fSD), and spectral properties of the EEG during quiet and active sleep were compared for both pre-and postoperative periods.ResultsAll infants showed significant differences in state-dependent variables between quiet and active sleep, both during preoperative (mean O 2 saturation= 80.9±2.8) and postoperative (mean O 2 saturation= 92.8±0.5) periods. As compared to preoperative period, postoperatively during quiet sleep, HR and HRSD were lower, and EEC power was greater; and during active sleep, HR, HRSD, and fSD decreased and EEG power increased. Also, in the postoperative period% quiet sleep increased and% active sleep decreased.ConclusionsUnder conditions of isocapnic hypoxemia infants with TCV vessels exhibit clearly recognizable states of sleep. Correction of hypoxemia is associated with significant changes in state-dependent variables both during quiet and active sleep.