A novel surgical treatment for long lasting unilateral peripheral parosmia: Olfactory cleft blocking technique
A novel surgical treatment for long lasting unilateral peripheral parosmia: Olfactory cleft blocking technique
复制标题
一种治疗持久性单侧周围性嗅觉异常的新颖手术方法：嗅裂阻断技术
DOI：
10.1016/j.anl.2020.07.018
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发表时间：
2020
影响因子：
1.7
通讯作者：
Wang Yibei
中科院分区：
文献类型：
--
作者：
Liu Jianfeng;Pinheiro-Neto CD;Jianhui Zhao;Chen Zhongyan;Wang Yibei
定性嗅觉疾病的治疗具有挑战性。我们的目的是治疗嗅觉异常使用一种新的微创手术技术-嗅裂封闭技术-通过防止气味到达嗅觉上皮。一种新的手术程序，封闭前和下开口的嗅裂完成了单侧持续性周围嗅觉异常的患者。术前、术后均行HRCT及鼻内镜检查，评价嗅裂的解剖结构。采用T&T嗅觉仪对术前、术后患者的嗅觉功能进行评估。手术后，患者嗅觉异常消失。内视镜检查及电脑断层扫描显示嗅裂前部及下部完全阻塞。在2年的随访期间没有复发报告。除手术中嗅觉丧失外，无手术并发症报告。对于长期单侧外周嗅觉功能障碍的患者，嗅裂封闭技术是一种新颖、简单、安全、有效的治疗方法。需要对更多患者进行进一步研究，以获得成功率。
The treatment of qualitative olfactory disease is challenging. We aimed to treat parosmia using a new minimally invasive surgical technique-the olfactory cleft blocking technique- by preventing odorants from reaching the olfactory epithelium. A novel surgical procedure for blocking the anterior and inferior openings of the olfactory cleft was accomplished in a patient with unilateral persistent peripheral parosmia. The HRCT and endoscopy were performed preoperatively and postoperatively to evaluate the anatomical structure of the olfactory cleft. The T&T olfactometer was used to assess the preoperative and postoperative olfactory function. After surgery, the patient's parosmia disappeared. Endoscopic examination and CT scan showed complete obstruction of the anterior and inferior portions of the olfactory cleft. No recurrence was reported during a 2-year follow-up. No surgical complications were reported except olfactory loss in the operative nostril. For patients with long-term unilateral peripheral olfactory dysfunction, the olfactory cleft blocking technique seems a novel, simple, safe and effective treatment. Further studies are required with a larger number of patients in order to access success rate.