Experimental Models for the Study of Female and Male Sexual Function
Experimental Models for the Study of Female and Male Sexual Function
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DOI：
10.1111/j.1743-6109.2010.01960.x
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发表时间：
2010-09-01
影响因子：
3.5
通讯作者：
Wallen, Kim
中科院分区：
文献类型：
--
作者：
Giuliano, Francois;Pfaus, James;Wallen, Kim
通过对动物模型的临床前研究，在了解人类性功能的生理和药理机制方面取得了重大进展。目的：提供证据-基于文献的实验模型评估男性和女性的性功能的有用的临床翻译。方法。在过去的18个月的共识讨论，导致来自6个国家的7位专家的意见总结。主要结果测量。报告是基于对文献和小组委员会报告、讨论以及思想和反馈交流中提供的科学信息的批判性分析。结果。动物模型的基础研究已经导致对欲望、唤醒、生殖器、生殖器和生殖器的生理机制的相当程度的理解。和其他性反应以及设计合理的药物治疗男性和女性的某些性功能障碍。组织和细胞的体外系统提供了关键的信息，在体内的相互作用和调制的存在和不存在的化学，生物，血管，神经，内分泌和遗传输入。动物模型似乎是必不可少的，以阐明生物生理学和病理学方面的男性和女性sexual disorders.Conclusions.有用的见解，人类的经验已经从基础研究的方式，是更难以获得在人类中，无论是科学和伦理。具有良好预测价值的动物模型可以作为成功的临床前工具，只要功能终点是同源或类似的。关键问题是是否需要进一步的评估来推断临床环境中的结果。Giuliano F，Pfaus J，Balasubramanian S，Hedlund P，Hisasue S，Marson L，and Wallen K.用于研究女性和男性性功能的实验模型。J Sex Med 2010;7：2970-2995.
Introduction.Significant progress has been made in the understanding of physiological and pharmacological mechanisms of human sexual functioning through preclinical research in animal models.Aim.To provide an evidence-based documentation of the experimental models evaluating male and female sexual function for useful clinical translation.Methods.Consensus discussion over the past 18 months leading to summarized views of seven experts from six countries.Main Outcome Measure.Report was based on the critical analysis of scientific information available in literature and subcommittee presentations, discussions, and exchanges of ideas and feedback.Results.Fundamental research in animal models has led to considerable understanding of the physiological mechanisms underlying desire, arousal, genital, and other sexual responses and the design of rational pharmacological treatments for certain sexual dysfunctions in the male and female. Tissue and cellular in vitro systems have provided critical information on the in vivo interactions and modulations in the presence and absence of chemical, biological, vascular, neurologic, endocrine, and genetic inputs. The animal models seem indispensable for elucidating the biophysiological and etiopathological aspects of male and female sexual disorders.Conclusions.Useful insights into the human experience have been derived from basic research in ways that are far more difficult to obtain in humans, both scientifically and ethically. The animal model with a good predictive value can be used as a successful preclinical tool so long as the functional end points are homologous or analogous. The key issue is whether further evaluations are warranted to extrapolate the results in a clinical setting. Giuliano F, Pfaus J, Balasubramanian S, Hedlund P, Hisasue S, Marson L, and Wallen K. Experimental models for the study of female and male sexual function. J Sex Med 2010;7:2970-2995.