L-DOPA reverses motor deficits associated with normal aging in mice.
L-DOPA reverses motor deficits associated with normal aging in mice.
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DOI：
10.1016/j.neulet.2010.11.054
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发表时间：
2011-02-01
影响因子：
2.5
通讯作者：
Cavanaugh JE
中科院分区：
文献类型：
--
作者：
Allen E;Carlson KM;Zigmond MJ;Cavanaugh JE
We wished to determine whether L-DOPA, a common treatment for the motor deficits in Parkinson's disease, could also reverse the motor deficits that occur during aging. We assessed motor performance in young (2-3 months) and old (20-21 months) male C57BL/6 mice using the challenge beam and cylinder tests. Prior to testing, mice were treated with L-DOPA or vehicle. Following testing, striatal tissue was analyzed for phenotypic markers of dopamine neurons: dopamine, dopamine transporter, and tyrosine hydroxylase. Although the dopaminergic markers were unchanged with age or L-DOPA treatment, L-DOPA reversed the motor deficits in the old animals such that their motor coordination was that of a young mice. These findings suggest that some of the locomotor deficits that accompany normal aging are responsive to L-DOPA treatment and may be due to subtle alterations in dopaminergic signaling.
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影响因子：
4.2
作者：
Salvatore, MF;Apparsundaram, S;Gerhardt, GA
通讯作者：
Gerhardt, GA
DOI：
10.1073/pnas.0702753104
发表时间：
2007-08-21
影响因子：
11.1
作者：
Rommelfanger, K. S.;Edwards, G. L.;Weinshenker, D.
通讯作者：
Weinshenker, D.
影响因子：
5.3
作者：
Fleming, SM;Zhu, CN;Chesselet, MF
通讯作者：
Chesselet, MF
影响因子：
5.3
作者：
Fleming, SM;Salcedo, J;Chesselet, MF
通讯作者：
Chesselet, MF
影响因子：
2.9
作者：
MCNEILL, TH;KOEK, LL
通讯作者：
KOEK, LL