Moderating role of the MAOA genotype in antisocial behaviour
Moderating role of the MAOA genotype in antisocial behaviour
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DOI：
10.1192/bjp.bp.111.093328
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发表时间：
2012-02-01
影响因子：
10.5
通讯作者：
Kennedy, Martin A.
中科院分区：
文献类型：
--
作者：
Fergusson, David M.;Boden, Joseph M.;Kennedy, Martin A.
背景最近的研究已经检查了基因x环境（G x E）的相互作用，涉及单胺氧化酶A（MAOA）基因在调节暴露于逆境和反社会行为之间的关联。本研究探讨了一种新的方法，用于评估一个单一的基因和多个风险因素之间的相互作用，与环境和个人advertisement.AimsTo测试的假设，即存在的低活性MAOA基因型与一系列的风险factors.MethodParticipants反应增加399男性从基督城健康与发展研究谁有完整的数据：（a）MAOA启动子区可变数目串联重复基因型;（B）反社会行为（c）母亲在怀孕期间吸烟，智商，儿童期虐待和学业失败。ResultsPoisson回归模型拟合三个反社会行为的结果（财产/暴力犯罪年龄15-30岁;定罪年龄17-21岁），使用暴露于不利童年环境的措施。分析揭示了一致的证据G x E的相互作用，使那些与低活性MAOA变异谁暴露在逆境中的童年显着更有可能报告犯罪在青春期后期和成年早期。ConclusionsThe目前的研究结果增加的证据表明，有一个稳定的G x E的相互作用，涉及MAOA，一系列不利的环境和个人因素，和反社会行为的影响这些分析还表明使用多种环境/个人暴露来测试G x E相互作用的实用性。
BackgroundRecent studies have examined gene x environment (G x E) interactions involving the monoamine oxidase A (MAOA) gene in moderating the associations between exposure to adversity and antisocial behaviour. The present study examined a novel method for assessing interactions between a single gene and multiple risk factors related to environmental and personal adversity.AimsTo test the hypothesis that the presence of the low-activity MAOA genotype was associated with an increased response to a series of risk factors.MethodParticipants were 399 males from the Christchurch Health and Development Study who had complete data on: (a) MAOA promoter region variable number tandem repeat genotype; (b) antisocial behaviour (criminal offending) to age 30 and convictions to age 21; and (c) maternal smoking during pregnancy, IQ, childhood maltreatment and school failure.ResultsPoisson regression models were fitted to three antisocial behaviour outcomes (property/violent offending ages 15-30; and convictions ages 17-21), using measures of exposure to adverse childhood circumstances. The analyses revealed consistent evidence of G x E interactions, such that those with the low-activity MAOA variant who were exposed to adversity in childhood were significantly more likely to report offending in late adolescence and early adulthood.ConclusionsThe present findings add to the evidence suggesting that there is a stable G x E interaction involving MAOA, a range of adverse environmental and personal factors, and antisocial behaviour across the life course. These analyses also demonstrate the utility of using multiple environmental/personal exposures to test G x E interactions.