Multifunctional isoquinoline-oxazoline ligands of chemical and biological importance
Multifunctional isoquinoline-oxazoline ligands of chemical and biological importance
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具有化学和生物学重要性的多功能异喹啉-恶唑啉配体
DOI：
10.1039/c9cc01790a
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发表时间：
2019
影响因子：
4.9
通讯作者：
Shengkun Li
中科院分区：
文献类型：
--
作者：
Wei Li;Guotong Wang;Jixing Lai;Shengkun Li
以市售手性氨基酸为原料，合成了多功能异喹啉-恶唑啉（MIQOXs）。通过pd催化的芳基硼酸对硝基苯乙烯的高对映选择性加成以及新的抗真菌候选物的发现，证明了MIQOXs的多功能作用。
Multifunctional isoquinoline-oxazolines (MIQOXs) were conceived and synthesized from commercially available chiral amino acids. The multifunctional role of MIQOXs was demonstrated by Pd-catalyzed highly enantioselective addition of arylboronic acids to nitrostyrenes, and by the discovery of novel antifungal candidates.