Do perfluoroalkyl substances affect metabolic function and plasma lipids?-Analysis of the 2007-2009, Canadian Health Measures Survey (CHMS) Cycle 1
Do perfluoroalkyl substances affect metabolic function and plasma lipids?-Analysis of the 2007-2009, Canadian Health Measures Survey (CHMS) Cycle 1
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DOI：
10.1016/j.envres.2012.11.006
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发表时间：
2013-02-01
影响因子：
8.3
通讯作者：
Haines, Douglas A.
中科院分区：
文献类型：
--
作者：
Fisher, Mandy;Arbuckle, Tye E.;Haines, Douglas A.
背景：全氟化合物（pfc）是一种人造化学物质，具有热稳定性、不可燃性，并且能够排斥水和油。生物监测研究表明这些化学物质在人类、动物和水生环境中的全球分布。pfc已被证明可以激活过氧化物酶体增殖体激活受体，这些受体在代谢和能量稳态调节中发挥重要作用。先前的流行病学研究也表明，PFCs对脂质和葡萄糖代谢有潜在作用。目的：本研究的目的是研究全氟化合物全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）和全氟己烷磺酸（PFHxS）在血浆中的含量与代谢功能和血脂水平之间的关系。方法：使用加拿大健康措施调查（2007-2009年第1周期）的横断面数据，我们使用多元线性和逻辑回归模型研究了成人血浆中PFOA、PFOS和PFHxS （n=2700）水平与胆固醇结局、代谢综合征和葡萄糖稳态之间的关系。结果：我们发现了一些证据，表明全氟烷基物质，特别是PFHxS，与总胆固醇（TC）、低密度脂蛋白胆固醇（LDL）、总胆固醇/高密度脂蛋白胆固醇比率（TC/HDL）和非高密度脂蛋白胆固醇之间存在显著关联，以及高胆固醇的几率升高。我们在未加权的模型中发现了PFOA和PFOS的一些关联，但这些结果在抽样策略加权后并不显著。我们没有发现与代谢综合征或葡萄糖稳态参数相关。结论：与其他已发表的人群研究相比，本研究显示PFOA和PFOS的水平较低，PFHxS的水平略高。我们的研究结果没有提供显著的证据来支持PFOS和PFOA与胆固醇结果的关联。然而，我们确实观察到PFHxS与胆固醇结局（LDL， TC, NON-HDL， TC/HDL比率）之间存在一些显著关联。爱思唯尔公司版权所有版权所有。
Background: Perfluorinated compounds (PFCs) are man-made chemicals that are heat stable, nonflammable and able to repel both water and oils. Biomonitoring research shows global distribution in human, animal and aquatic environments of these chemicals. PFCs have been shown to activate the peroxisome proliferator-activated receptors which play a large role in metabolism and the regulation of energy homeostasis. Previous epidemiological research has also suggested a potential role of PFCs on lipid and glucose metabolism.Objectives: The objectives of this study were to examine the association between the levels of perfluorinated compounds perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonate (PFHxS) in plasma and metabolic function and plasma lipid levels.Methods: Using cross-sectional data from the Canadian Health Measures Survey (Cycle 1 2007-2009) we examined the association in adults between plasma levels of PFOA, PFOS and PFHxS (n=2700) on cholesterol outcomes, metabolic syndrome and glucose homeostasis using multivariate linear and logistic regression models.Results: We found some evidence of a significant association between perfluoroalkyl substances, notably PFHxS, with total cholesterol (TC), low-density lipoprotein cholesterol (LDL), total cholesterol/high density lipoprotein cholesterol ratio (TC/HDL) and non-HDL cholesterol as well as an elevated odds of high cholesterol. We found some associations with PFOA and PFOS in our unweighted models but these results did not remain significant after weighting for sampling strategy. We found no association with metabolic syndrome, or glucose homeostasis parameters.Conclusions: This study showed lower levels of PFOA and PFOS and slightly higher levels of PFHxS than other published population studies. Our results did not give significant evidence to support the association with cholesterol outcomes with PFOS and PFOA. However, we did observe several significant associations with the PFHxS and cholesterol outcomes (LDL, TC, NON-HDL, TC/HDL ratio). Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.