A rare natural lipid induces neuroglobin expression to prevent amyloid oligomers toxicity and retinal neurodegeneration
A rare natural lipid induces neuroglobin expression to prevent amyloid oligomers toxicity and retinal neurodegeneration
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一种罕见的天然脂质诱导神经红蛋白表达，以防止淀粉样蛋白寡聚物毒性和视网膜神经变性
DOI：
10.1101/2021.06.23.449608
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Oamen H
中科院分区：
文献类型：
--
作者：
Oamen H
Most neurodegenerative diseases such as Alzheimer's disease are proteinopathies linked to the toxicity of amyloid oligomers. Treatments to delay or cure these diseases are lacking. Using budding yeast, we report that the natural lipid tripentadecanoin induces expression of the nitric oxide oxidoreductase Yhb1 to prevent the formation of protein aggregates during aging and extends replicative lifespan. In mammals, tripentadecanoin induces expression of the Yhb1 orthologue, neuroglobin, to protect neurons against amyloid toxicity. Tripentadecanoin also rescues photoreceptors in a mouse model of retinal degeneration and retinal ganglion cells in a Rhesus monkey model of optic atrophy. Together, we propose that tripentadecanoin affects p‐bodies to induce neuroglobin expression and offers a potential treatment for proteinopathies and retinal neurodegeneration.
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影响因子：
7.2
作者：
Radouil Tzekov;Linda Stein;S. Kaushal
通讯作者：
Radouil Tzekov;Linda Stein;S. Kaushal
内质网结合分子伴侣的区室化将蛋白质沉积物的形成限制在衰老的酵母细胞中
影响因子：
9.2
作者：
J. Saarikangas;Fabrice Caudron;Rupali Prasad;David F. Moreno;A. Bolognesi;M. Aldea;Y. Barral
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Y. Barral
影响因子：
56.9
作者：
Babcock, M;deSilva, D;Kaplan, J
通讯作者：
Kaplan, J
DOI：
10.1073/pnas.090083597
发表时间：
2000-04-25
影响因子：
11.1
作者：
Liu, LM;Zeng, M;Stamler, JS
通讯作者：
Stamler, JS
影响因子：
3.8
作者：
Lewinska, Anna;Bartosz, Grzegorz
通讯作者：
Bartosz, Grzegorz