Factors that affect acceptance of HIV microbicides among women
Factors that affect acceptance of HIV microbicides among women
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DOI：
10.1016/j.colegn.2011.09.006
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发表时间：
2012-01-01
期刊：
影响因子：
1.5
通讯作者：
Teitelman, Anne M.
中科院分区：
文献类型：
--
作者：
Domanska, Catherine A.;Teitelman, Anne M.
在全球范围内，女性占艾滋病毒感染者的一半以上。对于世界上几乎每个地区的妇女来说，艾滋病毒的主要传播方式是通过异性性行为。然而，在艾滋病毒/艾滋病流行三十多年后，妇女仍然缺乏足够的手段来保护自己免受艾滋病毒的感染。阴道HIV微生物剂(VHMs)是一种很有前途的预防HIV感染的新方法。VHM是一种化学物质，一旦病毒进入目标细胞，就可以摧毁艾滋病毒，阻止其进入目标细胞或与目标细胞融合，或抑制艾滋病毒的复制。它们可以通过不同的阴道内分娩方式使用。VHM是为妇女使用而设计的，为此，至关重要的是了解妇女对配方、使用和其他特征的偏好，以便确定如何提高遵从性和可接受性。特别要考虑的是，关系动态将如何影响杀微生物剂的使用。本综述的目的是审查关于男性和女性对VHM预防艾滋病毒从男性传播到女性的看法的最新文献，以更好地了解影响VHM在女性中使用的依从性和可接受性的因素。更好地了解影响VHM依从性和接受度的因素将对VHM的吸收产生影响，使护士和其他卫生保健提供者能够更有效地就VHM的使用向客户提供咨询，并指出未来研究和开发VHM所需的新方向。(C)2011年，澳大利亚皇家护理学院。由澳大利亚爱思唯尔出版(Reed International Books Australia Pty Ltd.的一个部门)。版权所有。
Globally, women make up more than half of those infected with HIV. For women in nearly every region around the world, the primary mode of HIV transmission is through heterosexual sex. However, over thirty years into the HIV/AIDS epidemic women still lack sufficient means of protecting themselves against HIV. Vaginal HIV microbicides (VHMs) are a promising new method to prevent HIV infection. VHMs are chemical substances that can destroy HIV, block its entry into or fusion with the target cell or inhibit HIV replication once the virus has entered a target cell. They can be applied through various delivery methods intravaginally. VHMs are designed to be used by women and to that end it is crucial to understand women's preferences for formulation, use and other characteristics in order to determine how to increase adherence and acceptability. Of particular consideration is how relationship dynamics will affect microbicide usage. The purpose of this review is to examine the most recent body of literature regarding male and female perceptions of VHMs to prevent male to female transmission of HIV in order to gain a greater understanding of the factors that affect adherence and acceptability of VHM usage among women. A greater understanding of the factors that affect adherence and acceptance of VHMs will have an impact on the uptake of VHMs, allow nurses and other health care providers to counsel clients more effectively about their use and point to new directions needed on the research and development of future microbicides. (C) 2011 Royal College of Nursing, Australia. Published by Elsevier Australia (a division of Reed International Books Australia Pty Ltd). All rights reserved.