Neutrophil Extracellular Traps and Microcrystals.
Neutrophil Extracellular Traps and Microcrystals.
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DOI：
10.1155/2017/2896380
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发表时间：
2017
影响因子：
4.1
通讯作者：
Rada B
中科院分区：
文献类型：
--
作者：
Rada B
中性粒细胞的胞外陷阱代表了一种迷人的机制，通过这种机制，PMNs捕获胞外微生物。这种先天免疫机制的主要目的被认为是在早期阶段定位感染。有趣的是，最近已经描述了不同微晶诱导NET形成的能力。微晶是具有不同组成和形状的尺寸为1-100微米的不溶性晶体。微晶有一个共同点，即它们刺激包括中性粒细胞在内的吞噬细胞，并通常引发炎症反应。这篇综述是第一个总结观察方面的PMN激活和NET释放诱导的微晶。引起痛风的尿酸盐结晶，引起假性痛风的焦磷酸钙结晶，与动脉粥样硬化有关的胆固醇结晶，引起硅肺病的二氧化硅结晶和佐剂明矾结晶进行了讨论。
Neutrophil extracellular traps represent a fascinating mechanism by which PMNs entrap extracellular microbes. The primary purpose of this innate immune mechanism is thought to localize the infection at an early stage. Interestingly, the ability of different microcrystals to induce NET formation has been recently described. Microcrystals are insoluble crystals with a size of 1–100 micrometers that have different composition and shape. Microcrystals have it in common that they irritate phagocytes including PMNs and typically trigger an inflammatory response. This review is the first to summarize observations with regard to PMN activation and NET release induced by microcrystals. Gout-causing monosodium urate crystals, pseudogout-causing calcium pyrophosphate dehydrate crystals, cholesterol crystals associated with atherosclerosis, silicosis-causing silica crystals, and adjuvant alum crystals are discussed.