Prevalence of baseline serum glucose and lipid testing in users of second-generation antipsychotic drugs: A retrospective, population-based study of medicaid claims data
Prevalence of baseline serum glucose and lipid testing in users of second-generation antipsychotic drugs: A retrospective, population-based study of medicaid claims data
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DOI：
10.4088/jcp.v69n0219
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发表时间：
2008-02-01
影响因子：
5.3
通讯作者：
Valuck, Robert J.
中科院分区：
文献类型：
--
作者：
Morrato, Elaine H.;Newcomer, John W.;Valuck, Robert J.
目的：糖尿病和血脂异常的风险增加与主要精神疾病和抗精神病药物的使用有关。本研究的目的是确定在公共精神卫生客户启动第二代抗精神病药（SGA）drugs.Method的患病率血糖和血脂监测：这一回顾性队列研究使用医疗补助索赔数据从加州，俄勒冈州，田纳西州和犹他州评估了55,436登记与处方索赔的SGA药物之间的1998年1月1日，2003年12月31日。使用现行程序术语（CPT）程序代码确定血糖和血脂检测。基线定义为首次SGA处方日期之前14天至之后28天。多变量逻辑回归确定与测试相关的患者特征。广义估计方程评估了与SGA药物启动相关联的变化相比，背景率testing.Results：平均而言，< 20%的个体启动SGA药物治疗接受基线血糖检测，< 10%接受基线血脂检测。基线血糖和血脂检测随着SGA的开始适度增加（血糖：增加7%-11%;血脂：增加2%-3%; p
Objective: Increased risk of diabetes and dyslipidemia is associated with major mental illness and antipsychotic drug use. This study aimed to determine the prevalence of serum glucose and lipid monitoring in public mental health clients initiating second-generation antipsychotic (SGA) drugs.Method: This retrospective cohort study using Medicaid claims data from California, Oregon, Tennessee, and Utah evaluated 55,436 enrollees with a prescription claim for an SGA drug between January 1, 1998, and December 31, 2003. Serum glucose and lipid testing were identified using Current Procedural Terminology (CPT) procedure codes. Baseline was defined as 14 days before through 28 days after the date of the first SGA prescription. Multivariate logistic regression identified patient characteristics associated with testing. Generalized estimating equations evaluated changes associated with SGA drug initiation compared to background rates of testing.Results: On average, < 20% of individuals initiating SGA drug therapy received baseline glucose testing, and < 10% received baseline lipid testing. Baseline glucose and lipid testing increased modestly with SGA initiation (glucose: 7%-11% increase: lipids: 2%-3% increase; p