Clostridium difficile suppresses colonic vasoactive intestinal peptide associated with altered motility.
Clostridium difficile suppresses colonic vasoactive intestinal peptide associated with altered motility.
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DOI：
10.1155/s096293519500072x
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发表时间：
1995
影响因子：
4.6
通讯作者：
Kaminski DL
中科院分区：
文献类型：
--
作者：
Nassif A;Longo WE;Sexe R;Stratton M;Standeven J;Vernava AM;Kaminski DL
我们研究了艰难梭菌毒素是否会改变结肠组织中血管活性肠肽（VIP）的水平，在离体灌流兔左结肠的结肠动力的变化为代价。通过结肠内给予10 - 8 M C诱导结肠炎症。艰难毒素将应变传感器缝在结肠的浆膜表面上以评估结肠动力。C. difficile给药产生与上皮损伤一致的组织学变化。这与前列腺素E2和血栓素B2的产生增加有关。VIP而不是P物质的组织水平显著降低。这与每分钟收缩次数的增加和每次结肠收缩的平均力有关。这些结果表明，VIP的组织水平被C。在活动性炎症过程中，可能参与结肠动力障碍。
We investigated whether Clostridium difficile toxin alters colonic tissue levels of vasoactive intestinal peptide (VIP) at the expense of changes in colonic motility in the isolated perfused rabbit left colon. Colonic inflammation was induced by the intracolonic administration of 10−8 M C. difflcile toxin. Strain gauge transducers were sewn onto the serosal surface of the colon to evaluate colonic motility. C. difflcile administration produced histologic changes consistent with epithelial damage. This was associated with an increased production of prostaglandin E2 and thromboxane B2. Tissue levels of VIP but not substance P were significantly reduced. This was associated with an increased number of contractions per minute and an average force of each colonic contraction. These results suggest that tissue levels of VIP are suppressed by C. difflcile and may participate in colonic dysmotility during active inflammation.