PULMONARY NEUROENDOCRINE CELLS - THEIR SECRETORY PRODUCTS AND THEIR POTENTIAL ROLES IN HEALTH AND CHRONIC LUNG-DISEASE IN INFANCY
PULMONARY NEUROENDOCRINE CELLS - THEIR SECRETORY PRODUCTS AND THEIR POTENTIAL ROLES IN HEALTH AND CHRONIC LUNG-DISEASE IN INFANCY
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DOI：
10.1164/ajrccm/140.6.1807
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发表时间：
1989-12-01
期刊：
影响因子：
--
通讯作者：
GEORGIEFF, MK
中科院分区：
文献类型：
--
作者：
JOHNSON, DE;GEORGIEFF, MK
Pulmonary neuroendocrine cells (PNEC) are granulated epithelial cells distributed throughout conducting airways. Among the bloactlve products Identified within the secretory granules of these cells are potent mltogens and bronchoactlve and vasoactive agents. The secretory status of these cells, which are In greatest number In the fetus and newborn, Is modulated by neural reflexes and by changes In airway gas composition. The aggregate data suggest roles for PNEC in airway" chemoceptlon" and/or regulation of airway epithelial dlfferentlon. Marked Increases In
