The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila.
The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila.
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非受体蛋白酪氨酸磷酸酶螺旋在果蝇的多个受体酪氨酸激酶途径中发挥作用。
DOI：
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发表时间：
1996
影响因子：
2.7
通讯作者：
Norbert Perrimon
中科院分区：
文献类型：
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作者：
Liz Perkins;Michelle R. Johnson;Michael Melnick;Norbert Perrimon
Corkscrew（csw）编码一种非受体蛋白酪氨酸磷酸酶（PTH 4），该酶与来自躯干受体酪氨酸激酶（RTK）的信号传导有关。与TOR突变不同，Csw突变与合子致死性相关，表明Csw在发育过程中起着额外的作用。我们对csw突变进行了详细的表型分析，以确定Csw的这些额外功能。我们的研究结果表明，Csw积极运作的其他果蝇RTK，如果蝇表皮生长因子受体（DER），成纤维细胞生长因子受体（气喘吁吁），和可能的其他RTK下游。该模型通过csw和DER之间的特定剂量相互作用得到证实。有人提出，Csw是进化上保守的“信号盒”的一部分，其在所有RTK的下游操作。为了支持这一假设，我们证明了SHP-2，一种与Csw相似的脊椎动物PTO 2，以前参与RTK信号传导，编码Csw的功能性脊椎动物同源物。
Corkscrew (csw) encodes a nonreceptor protein tyrosine phosphatase (PTPase) that has been implicated in signaling from the Torso receptor tyrosine kinase (RTK). csw mutations, unlike tor mutations, are associated with zygotic lethality, indicating that Csw plays additional roles during development. We have conducted a detailed phenotypic analysis of csw mutations to identify these additional functions of Csw. Our results indicate that Csw operates positively downstream of other Drosophila RTKs such as the Drosophila epidermal growth factor receptor (DER), the fibroblast growth factor receptor (Breathless), and likely other RTKs. This model is substantiated by specific dosage interactions between csw and DER. It is proposed that Csw is part of the evolutionarily conserved "signaling cassette" that operates downstream of all RTKs. In support of this hypothesis, we demonstrate that SHP-2, a vertebrate PTPase similar to Csw and previously implicated in RTK signaling, encodes the functional vertebrate homologue of Csw.
果蝇胚胎发生过程中多次需要鱼雷 (DER) 受体酪氨酸激酶。
DOI：
10.1242/dev.115.3.853
发表时间：
1992
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Clifford,R;Schüpbach,T
通讯作者：
Schüpbach,T