Measurement of tumor volume by PET to evaluate prognosis in patients with advanced cervical cancer treated by radiation therapy
Measurement of tumor volume by PET to evaluate prognosis in patients with advanced cervical cancer treated by radiation therapy
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DOI：
10.1016/s0360-3016(02)02705-0
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发表时间：
2002-06-01
影响因子：
7
通讯作者：
Grigsby, PW
中科院分区：
文献类型：
--
作者：
Miller, TR;Grigsby, PW
目的：本研究评估肿瘤体积测量与正电子发射断层扫描（PET）的放射治疗晚期宫颈癌患者的有用性。方法和材料：51例患者接受PET治疗前。原发肿瘤体积的确定，体积，FIGO分期，并在PET研究淋巴结的存在进行了比较，无进展生存期（PFS）和总生存期（OS）。结果：肿瘤体积，淋巴结疾病和阶段预测PFS，而体积和淋巴结受累预测OS。淋巴结状态与体积无关。根据肿瘤体积是否大于或小于60 cm（3）对患者进行分类可预测PFS和OS。将肿瘤体积小于或等于60 cm（3）且无淋巴结疾病的患者与任何其他组合的患者分开可强烈预测PFS和OS。结论：关于接受放射治疗的晚期宫颈癌患者，得出以下结论：（1）PET可以准确测量肿瘤体积;（2）肿瘤体积将预后良好的患者与预后较差的患者区分开来;（3）肿瘤相对较小且无淋巴结受累的患者亚组表现非常好;（4）肿瘤体积与淋巴结疾病的存在无关。(C)2002年爱思唯尔科学公司
Purpose: This study evaluated the usefulness of tumor volume measurement with positron emission tomography (PET) in patients with advanced cervical cancer treated by radiation therapy.Methods and Materials: Fifty-one patients underwent PET before treatment. Primary tumor volume was determined, and volume, FIGO stage, and presence of lymph nodes on the PET study were compared to progression-free survival (PFS) and overall survival (OS).Results: Tumor volume, lymph node disease, and stage were predictive of PFS, whereas volume and lymph node involvement predicted OS. Lymph node status did not correlate with volume. Dividing patients according to whether the tumor volume was more or less than 60 cm(3) predicted PFS and OS. Separation of patients with tumor volumes less than or equal to60 cm(3) and no lymph node disease vs. any other combination was strongly predictive of PFS and OS.Conclusions: The following conclusions were drawn regarding patients with advanced cervical cancer treated with radiation therapy: (1) Tumor volume can be accurately measured by PET; (2) Tumor volume separates patients with a good prognosis from those with a poorer prognosis; (3) A subset of patients with relatively small tumors and no lymph node involvement does remarkably well; (4) Tumor volume does not correlate with the presence of lymph node disease. (C) 2002 Elsevier Science Inc.