Proof of concept: Effect of GLP-1 agonist on food hedonic responses and taste sensitivity in poor controlled type 2 diabetic patients
Proof of concept: Effect of GLP-1 agonist on food hedonic responses and taste sensitivity in poor controlled type 2 diabetic patients
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DOI：
10.1016/j.dsx.2019.06.021
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发表时间：
2019-07-01
影响因子：
10
通讯作者：
Penicaud, Luc
中科院分区：
文献类型：
--
作者：
Brindisi, Marie-Claude;Brondel, Laurent;Penicaud, Luc
目的：GLP-1类似物减少食物摄入，在对抗肥胖方面有很大的前景。关于它们对控制不佳的2型糖尿病（T2 D）患者的食物享乐感觉和味觉的影响知之甚少。材料和方法：在利拉鲁肽治疗前和治疗后3个月，研究了18名BMI >= 25 kg/m2且血糖控制不佳的T2 D患者。对几种食物的咸味、甜味和苦味、最佳偏好、嗅觉喜好、想要和回忆喜好的检测阈值进行了评估。受试者还回答了问卷调查，以衡量他们的态度food.Results：T2 D患者有一个显着的体重和HbA 1c与利拉鲁肽治疗后下降。利拉鲁肽改善了甜味的味觉检测阈值，减少了对甜食的需求，并回忆起了对脂肪食物的喜爱。结论：利拉鲁肽增加了对甜味的敏感性，降低了控制不良的T2 D患者对脂肪食物的愉悦反应，并且对了解减肥机制特别感兴趣。(C)2019印度糖尿病。由爱思唯尔有限公司出版。保留所有权利。
Aims: GLP-1 analogues decrease food intake and have great promise for the fight against obesity. Little is known about their effects on food hedonic sensations and taste perception in poor controlled patients with type 2 diabetes (T2D).Materials and methods: Eighteen T2D patients with BMI >= 25 kg/m(2) and poor controlled glycemia were studied before and after 3 months of treatment with Liraglutide. Detection thresholds for salty, sweet and bitter tastes, optimal preferences, olfactory liking, wanting and recalled liking for several food items were assessed. Subjects also answered questionnaires to measure their attitudes to food.Results: T2D patients had a significant decrease in bodyweight and HbA1c after treatment with Liraglutide. Liraglutide improved gustative detection threshold of sweet flavors, and decreased wanting for sweet foods and recalled liking for fatty foods. It also led to a decrease in feelings of hunger.Conclusions: Liraglutide increases sensitivity to sweet tastes and decreases pleasure responses for fatty foods in poor controlled T2D patients, and is of particular interest in the understanding of the mechanisms of weight loss. (C) 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.