Synthesis of some diguanidino 1-methyl-2,5-diaryl-1H-pyrroles as antifungal agents
Synthesis of some diguanidino 1-methyl-2,5-diaryl-1H-pyrroles as antifungal agents
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DOI：
10.1016/j.bmcl.2005.05.080
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发表时间：
2005-08-01
影响因子：
2.7
通讯作者：
Sinha, N
中科院分区：
文献类型：
--
作者：
Jana, GH;Jain, S;Sinha, N
以1-甲基-1H-吡咯为起始原料，合成了一系列新的2，5-二（胍基芳基）-1-甲基-1H-吡咯9a-h。采用体外琼脂扩散法和肉汤稀释法对化合物的抗念珠菌活性进行了评价。和曲霉属（Aspergillus spp.）发现来自该系列的化合物9 c与氟康唑等效或更有效，而化合物9d与氟康唑对大多数测试菌株相当。(c)2005爱思唯尔有限公司保留所有权利。
A series of novel 2,5-bis(guanidino-aryl)-1-methyl-1H-pyrroles 9a-h has been synthesized starting from 1-methyl-1H-pyrrole. The antifungal activities of compounds were evaluated by in vitro agar diffusion and broth dilution assay against Candida spp. and Aspergillus spp. Compound 9c from this series was found to be equipotent or more potent than fluconazole, whereas compound 9d was comparable to fluconazole against most of the tested strains. (c) 2005 Elsevier Ltd. All rights reserved.