Prevalence and mechanisms of gastro-oesophageal reflux in adult cystic fibrosis patients
Prevalence and mechanisms of gastro-oesophageal reflux in adult cystic fibrosis patients
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DOI：
10.1177/014107689809100103
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发表时间：
1998-01-01
影响因子：
17.3
通讯作者：
Walshaw, MJ
中科院分区：
文献类型：
--
作者：
Ledson, MJ;Tran, J;Walshaw, MJ
胃食管反流（戈尔）常发生在囊性纤维化（CF）儿童中，但尚未在成人CF中进行研究。对50例成人CF患者进行问卷调查（平均年龄26岁，范围16 - 50; 24名男性），并对10名有反流症状的患者进行食管测压和24小时pH记录（平均年龄28岁，范围21 - 35岁; 8名男性）。47名患者（94%）有上消化道症状：40名（80%）胃灼热（仰卧时27例加重）; 26例（52%）反流; 28例（56%）消化不良。在食管测压时，10名患者中有6名患者的下食管括约肌屏障压（LOSBP）低于正常值，3名患者的食管中段存在不协调的痉挛。8例患者的DeMeester评分升高，表明有显著的戈尔。LOSBP <5 mm Hg的患者DeMeester评分（平均81.0，范围47.9 - 128.8）高于LOSBP正常的患者（26.9，8.7 - 56.5; p <0.002）。这些结果表明，成年CF患者有较高的戈尔反应症状、降低的LOSBP和胃酸反流发生率。
Gastro-oesophageal reflux (GOR) occurs frequently in children with cystic fibrosis (CF) but has not been studied in adult CF. We surveyed such symptoms by structured questionnaire in 50 adult CF patients (mean age 26 years, range 16-50; 24 male) and performed oesophageal manometry and 24-hour pH recording in 10 who had reflux symptoms (mean age 28 years, range 21-35; 8 men).47 patients (94%) had upper gastrointestinal symptoms: 40 (80%) heartburn (27 worse when supine); 26 (52%) regurgitation; and 28 (56%) dyspepsia. At oesophageal manometry, lower oesophageal sphincter barrier pressure (LOSBP) was subnormal in 6 of the 10 patients and 3 had uncoordinated peristalsis in the mid oesophagus. 8 patients had raised DeMeester scores, indicating significant GOR. Those patients with a LOSBP < 5 mm Hg had a higher DeMeester score (mean 81.0, range 47.9-128.8) than the patients with a normal LOSBP (26.9, 8.7-56.5; p < 0.002).These results show that adult CF patients have high rates of GOR symptoms, diminished LOSBP, and acid reflux.