Symptom dimensions and functional impairment in early psychosis: more to the story than just negative symptoms.
Symptom dimensions and functional impairment in early psychosis: more to the story than just negative symptoms.
复制标题
DOI：
10.1016/j.schres.2013.03.024
复制
发表时间：
2013-06
影响因子：
4.5
通讯作者：
Loewy RL
中科院分区：
文献类型：
--
作者：
Fulford D;Niendam TA;Floyd EG;Carter CS;Mathalon DH;Vinogradov S;Stuart BK;Loewy RL
功能障碍是精神障碍的一个决定性特征，通常在发病前就出现了。阴性症状在精神分裂症患者和精神病临床高危人群（CHR）的功能受损中起着突出的作用。尽管在早期精神病中抑郁和焦虑的比例很高，但很少有研究调查这些症状对假定的“前驱症状”的功能的贡献。“在目前的研究中，我们检验了以下假设：1)在两组CHR个体（合并N = 98）和另一组新近发病（RO）精神障碍个体（N = 88）中，更严重的阴性和紊乱，但不是阳性症状与社会和角色功能受损显著相关；2)在两个样本中，更严重的焦虑和抑郁将与功能受损显著相关，超过阴性和紊乱症状的贡献。研究结果在很大程度上支持了我们的假设，即在两个样本中，更严重的阴性和紊乱症状与更差的社会和角色功能有关。在两个样本中，焦虑和抑郁的严重程度与较差的功能显著相关。此外，抑郁，而不是焦虑，预示着较差的全球和社会功能，超出了CHR样本中阴性症状所解释的范围。这些结果表明需要在早期精神病中进行阶段特异性治疗，重点关注症状维度以改善CHR个体的功能结局。
Functional impairment is a defining feature of psychotic disorders and usually appears well before their onset. Negative symptoms play a prominent role in the impaired functioning of individuals with schizophrenia and those at clinical-high-risk (CHR) for psychosis. Despite high rates of depression and anxiety in early psychosis, few studies have examined the contribution of these symptoms to functioning in the putative ‘prodrome.’ In the current study, we tested the hypotheses that 1) worse negative and disorganized, but not positive, symptoms would be significantly related to impaired social and role functioning in two cohorts of CHR individuals (combined N = 98) and a separate sample of individuals with recent-onset (RO) psychotic disorders (N = 88); and 2) worse anxiety and depression would be significantly related to impaired functioning in both samples, above and beyond the contributions of negative and disorganized symptoms. Findings largely supported our hypotheses that more severe negative and disorganized symptoms were related to poorer social and role functioning in both samples. Anxiety and depression severity were significantly related to poorer functioning in both samples. In addition, depression, but not anxiety, predicted poorer global and social functioning above and beyond that explained by negative symptoms in the CHR sample. These results suggest the need for phase-specific treatment in early psychosis, with a focus on symptom dimensions to improve functional outcomes for CHR individuals.
登录
查看更多内容
影响因子：
3.4
作者：
HALL, RCW
通讯作者：
HALL, RCW
影响因子：
2
作者：
Kim, Kyung Ran;Lee, Su Young;Kwon, Jun Soo
通讯作者：
Kwon, Jun Soo
影响因子：
6.7
作者：
Dickerson, FB;Ringel, NB;Parente, F
通讯作者：
Parente, F
DOI：
10.1176/jnp.23.4.jnp457
发表时间：
2011-09-01
影响因子：
2.9
作者：
Eslami, Ali;Jahshan, Carol;Cadenhead, Kristin S.
通讯作者：
Cadenhead, Kristin S.
影响因子：
4.5
作者：
Dragt, Sara;Nieman, Dorien H.;Linszen, Don H.
通讯作者：
Linszen, Don H.