Morphogen interpretation: the transcriptional logic of neural tube patterning
Morphogen interpretation: the transcriptional logic of neural tube patterning
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DOI：
10.1016/j.gde.2013.04.003
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发表时间：
2013-08-01
影响因子：
4
通讯作者：
Blassberg, Robert
中科院分区：
文献类型：
--
作者：
Cohen, Michael;Briscoe, James;Blassberg, Robert
发育组织中细胞命运的空间组织通常涉及形态发生梯度对转录网络的控制。这方面的一个研究充分的例子是脊椎动物神经管中神经元亚型分化的Sonic-hedgehog（Shh）控制模式。在这里，我们讨论了最近的研究，涉及全基因组分析，功能实验和理论模型，已经开始验证神经细胞解释Shh信号的分子逻辑。从这项工作中出现的观点是，细胞的身份是由Shh信号传导、均匀表达的神经因子和下游Shh靶基因的交叉调控网络的组合输入引起的。类似的逻辑也可能支撑许多发育中的组织的模式。
The spatial organization of cell fates in developing tissues often involves the control of transcriptional networks by morphogen gradients. A well-studied example of this is the Sonic-hedgehog (Shh) controlled pattern of neuronal subtype differentiation in the vertebrate neural tube. Here we discuss recent studies involving genome wide analyses, functional experiments and theoretical models that have begun to characterise the molecular logic by which neural cells interpret Shh signalling. The view that emerges from this work is that cell identity results from the combined input of Shh signalling, uniformly expressed neural factors and the cross-regulatory network of downstream Shh target genes. A similar logic is also likely to underpin the patterning of many developing tissues.