Synthesis and characteristics of polyelectrolyte complexes composed of chitosan and hyaluronic acid
Synthesis and characteristics of polyelectrolyte complexes composed of chitosan and hyaluronic acid
复制标题
DOI：
10.1002/app.13513
复制
发表时间：
2004-03-05
影响因子：
3
通讯作者：
Kim, SI
中科院分区：
文献类型：
--
作者：
Kim, SJ;Shin, SR;Kim, SI
制备了不同质量比的壳聚糖和透明质酸（HA）的聚电解质复合物（PEC）。佩奇通过带相反电荷的聚合物的反应形成。利用傅里叶变换红外光谱（FTIR）和差示扫描量热法（DSC）对PEC膜进行了表征。发现佩奇迅速溶胀，在30分钟内达到平衡，并且在室温下表现出250-325%的相对高的溶胀率。当缓冲液的pH低于pH 6时，由于离子键的解离，并且随着温度的增加，溶胀比增加。因此，膜的溶胀比是pH和温度依赖性的。DSC用于测定PEC膜中的游离水的量，其随着壳聚糖含量的增加而增加。(C)2004 Wiley Periodicals，Inc.
Polyelectrolyte complexes (PEC) composed of various weight ratios of chitosan and hyaluronic acid (HA) were prepared. The PECs were formed by a reaction of the oppositely charged polymers. The characterizations of the PEC films were investigated by using Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The PECs were found to swell rapidly, reaching equilibrium within 30 min, and exhibited relatively high swelling ratios of 250-325% at room temperature. The swelling ratio increased when the pH of the buffer was below pH 6, as a result of the dissociation of the ionic bonds, and with increments of temperature. Therefore, the swelling ratios of the films were pH and temperature dependent. DSC was used to determine the amount of free water in the PEC films, which increased with increasing chitosan content. (C) 2004 Wiley Periodicals, Inc.