Anti-angiogenic activity of tocotrienol
Anti-angiogenic activity of tocotrienol
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DOI：
10.1271/bbb.67.1623
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发表时间：
2003-07-01
影响因子：
1.6
通讯作者：
Miyazawa, T
中科院分区：
文献类型：
--
作者：
Inokuchi, H;Hirokane, H;Miyazawa, T
体外研究了维生素E化合物的抗血管生成特性，特别是对生育三烯醇的研究。生育三烯醇对牛主动脉内皮细胞的增殖和管状形成均有抑制作用，但对生育酚没有抑制作用，其中δ -生育三烯醇的抑制作用最强。此外，三角生育三烯醇还能减少人脐静脉内皮细胞在血管内皮生长因子刺激下形成的小管。我们的研究结果表明，生育三烯醇有可能作为一种治疗性膳食补充剂，以减少肿瘤血管生成。
The anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in vitro. Tocotrienol, but not tocopherol, inhibited both the proliferation and tube formation of bovine aortic endothelial cells, with delta-tocotrienol appearing the highest activity. Also, delta-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formation by human umbilical vein endothelial cells. Our findings suggest that tocotrienol has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis.