The presence of autoantibodies is associated with improved overall survival in lung cancer patients.
The presence of autoantibodies is associated with improved overall survival in lung cancer patients.
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DOI：
10.3389/fonc.2023.1234847
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Rong Wang
中科院分区：
文献类型：
--
作者：
Keying Jing;Huijuan Zhao;Jun Cai;Lianlian Chen;Peiming Zheng;Libo Ouyang;Gang Li;Rong Wang
Objective: Autoantibodies have been reported to be associated with cancers. As.a biomarker, autoantibodies have been widely used in the early screening of lung.cancer. However, the correlation between autoantibodies and the prognosis of.lung cancer patients is poorly understood, especially in the Asian population. This.retrospective study investigated the association between the presence of.autoantibodies and outcomes in patients with lung cancer..Methods: A total of 264 patients diagnosed with lung cancer were tested for.autoantibodies in Henan Provincial People’s Hospital from January 2017 to June.2022. The general clinical data of these patients were collected, and after.screening out those who met the exclusion criteria, 151 patients were finally.included in the study. The Cox proportional hazards model was used to analyze.the effect of autoantibodies on the outcomes of patients with lung cancer. The.Kaplan-Meier curve was used to analyze the relationship between.autoantibodies and the overall survival of patients with lung cancer..Results: Compared to lung cancer patients without autoantibodies, those with.autoantibodies had an associated reduced risk of death (HRs: 0.45, 95% CIs.0.27~0.77), independent of gender, age, smoking history, pathological type, and.pathological stage of lung cancer. Additionally, the association was found to be.more significant by subgroup analysis in male patients, younger patients, and.patients with small cell lung cancer. Furthermore, lung cancer patients with.autoantibodies had significantly longer survival time than those without.autoantibodies..Conclusion: The presence of autoantibodies is an independent indicator of good.prognosis in patients with lung cancer, providing a new biomarker for prognostic.evaluation in patients with lung cancer
