Atherosclerosis is not accelerated in rheumatoid arthritis of low activity or remission, regardless of antirheumatic treatment modalities
Atherosclerosis is not accelerated in rheumatoid arthritis of low activity or remission, regardless of antirheumatic treatment modalities
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DOI：
10.1093/rheumatology/kew506
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发表时间：
2017-06-01
期刊：
影响因子：
5.5
通讯作者：
Sfikakis, Petros P.
中科院分区：
文献类型：
--
作者：
Arida, Aikaterini;Protogerou, Athanasios D.;Sfikakis, Petros P.
目标. RA与由于加速动脉粥样硬化导致的心血管疾病（CVD）发病率和死亡率增加相关，这归因于经典危险因素和慢性炎症。本研究的目的是检验3年以上有效的疾病控制可以改变RA动脉粥样硬化加速的假设。方法。既往通过超声检查亚临床动脉粥样硬化的连续性非糖尿病RA患者在3.2（0.2）年后重新评估，前提是他们处于缓解/低疾病活动性（DAS 28
Objectives. RA associates with increased cardiovascular disease (CVD) morbidity and mortality due to accelerated atherosclerosis, attributed to both classical risk factors and chronic inflammation. The aim of this study was to test the hypothesis that effective disease control over 3 years modifies acceleration of atherosclerosis in RA.Methods. Consecutive, non-diabetic RA patients previously examined by ultrasonography for subclinical atherosclerosis were re-evaluated after 3.2 (0.2) years, provided that they were in remission/low disease activity (DAS28