The Automation of Science
The Automation of Science
复制标题
DOI：
10.1126/science.1165620
复制
发表时间：
2009-04-03
期刊：
影响因子：
56.9
通讯作者：
Clare, Amanda
中科院分区：
文献类型：
--
作者：
King, Ross D.;Rowland, Jem;Clare, Amanda
科学的基础是假设演绎方法和足够详细的实验记录以实现可重复性。我们报道机器人科学家“亚当”的发展，它推动了两者的自动化。 Adam 自主生成了有关酿酒酵母的功能基因组学假设，并通过实验室自动化对这些假设进行了实验测试。我们通过手工实验证实了Adam的结论。为了描述 Adam 的研究，我们开发了一种本体论和逻辑语言。由此产生的形式化涉及嵌套树状结构中的 10,000 多个不同的研究单位，深度为 10 层，将 660 万个生物量测量值与其逻辑描述联系起来。这种形式化描述了机器如何贡献科学知识。
The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist "Adam," which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge.