Fecal microbiota transplantation cured epilepsy in a case with Crohn's disease: The first report.
Fecal microbiota transplantation cured epilepsy in a case with Crohn's disease: The first report.
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粪便微生物群移植治愈了克罗恩病病例中的癫痫：第一份报告
DOI：
10.3748/wjg.v23.i19.3565
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发表时间：
2017-05-21
影响因子：
4.3
通讯作者：
Zhang FM
中科院分区：
文献类型：
--
作者：
He Z;Cui BT;Zhang T;Li P;Long CY;Ji GZ;Zhang FM
粪便微生物群移植（FMT）是一种很有前景的策略，涉及肠道微生物群的重建。最近，它被视为克罗恩病（CD）和某些神经系统疾病的一种治疗方法。在此，据我们所知，我们报告了首例使用FMT使一名患有克罗恩病且有17年癫痫病史的女孩的肠道和神经症状得到缓解的病例。在20个月的随访期间，FMT已证明其在停用抗癫痫药物后预防癫痫发作复发的功效。此外，这一发现凸显了微生物群 - 肠 - 脑轴的作用，并启发了通过重塑肠道微生物群治疗癫痫的新方法。
Fecal microbiota transplantation (FMT) is a promising strategy that involves reconstruction of gut microbiota. Recently, it has been considered as a treatment of Crohn’s disease (CD) and certain neurological diseases. Here, to the best of our knowledge, we report the first case that used FMT to achieve remission of intestinal and neurological symptoms in a girl with CD and a 17-year history of epilepsy. During the 20 mo of follow-up, FMT has proved its efficacy in preventing relapse of seizures after withdrawing the antiepileptic drugs. Furthermore, this finding highlights the role of microbiota-gut-brain axis and inspires a novel treatment for epilepsy through remodeling gut microbiota.