Activity in the human amygdala corresponds to early, rather than late period autonomic responses to a signal for shock
Activity in the human amygdala corresponds to early, rather than late period autonomic responses to a signal for shock
复制标题
DOI：
10.1101/lm.632007
复制
发表时间：
2007-07-01
影响因子：
2
通讯作者：
Helmstetter, Fred J.
中科院分区：
文献类型：
--
作者：
Cheng, Dominic T.;Richards, Jennifer;Helmstetter, Fred J.
实验动物和人类的研究表明，杏仁核是支持条件性恐惧获得和表达的关键大脑结构。最近的人类功能神经成像研究表明，该区域的活动与条件性皮肤电导反应(SCR)的行为表达密切相关。然而，条件刺激(CS)呈现后的SCR波形包含早期和晚期反应，这可能与潜在的中枢过程不同。目前尚不清楚杏仁核活动是否对应于早期条件性反应(CRS)的表达，这些CRS发生在CS发病后不久，还是晚CRS发生之前。本研究使用事件相关功能磁共振成像和同步皮肤电导测量来确定杏仁核活动是否与早期或晚期CRS的表达更密切相关。杏仁核活动在CRS形成的早期而不是晚期被检测到。此外，杏仁核的这种活动模式并没有消散，而是持续到实验的后期。这些发现与杏仁核反应与CS发病后不久形成的CRS的产生密切相关的观点一致。
Laboratory animal and human subject studies report that the amygdala is a critical brain structure that supports the acquisition and expression of conditional fear. Recent functional neuroimaging studies in humans have reported that activity in this region is closely related to the behavioral expression of conditional skin conductance responses ( SCR). However, SCR waveforms following conditional stimulus ( CS) presentation contain both early period and late period responses that may differ with respect to underlying central processes. It is not known whether amygdala activity corresponds to the expression of early conditonal responses ( CRs) that occur shortly following CS onset or late CRs that closely precede UCS onset. The present study used event- related functional magnetic resonance imaging and concurrent skin conductance measurements to determine whether amygdala activity is more closely related to the expression of early or late period CRs. Increased amygdala activity was detected during the formation of early, but not late period CRs. Additionally, this pattern of amygdala activity did not dissipate, but persisted into late stages of the experiment. These findings are consistent with the idea that amygdala responding is critically involved in the generation of CRs formed shortly following CS onset.