Cerebral mapping of apraxia in Alzheimer's disease by positron emission tomography
Cerebral mapping of apraxia in Alzheimer's disease by positron emission tomography
复制标题
通过正电子发射断层扫描对阿尔茨海默病失用症进行脑图绘制
作者：
N. Foster;T. Chase;N. Patronas;M. Gillespie;P. Fedio
在17名右利手阿尔茨海默病患者和6名年龄匹配的正常受试者中，将模仿熟练动作或对口头命令做出手势的能力与心理测量表现以及[18 F]氟脱氧葡萄糖正电子发射断层扫描估计的局部葡萄糖利用进行了比较。在命令和模仿测试中，失用症的得分在阿尔茨海默病患者中明显较低。模仿分数与视觉空间能力测试的表现和右顶叶的皮质代谢相关性最好;命令分数与反映语言能力的测试结果和左下半球的皮质代谢相关性最密切，特别是额叶。因此，对命令和模仿的失用症可能反映了阿尔茨海默病患者不同大脑区域的神经元功能障碍。
The ability to mimic skilled movements or to pantomime them in response to spoken command was compared with psychometric performance and with regional glucose utilization as estimated by [18F]fluorodeoxyglucose positron emission tomography in 17 right‐handed patients with Alzheimer's disease and 6 age‐matched normal subjects. Apraxia scores, both on tests to command and to imitation, were significantly lower in the Alzheimer patients. Imitation scores correlated best with performance on tests of visual–spatial ability and with cortical metabolism in the right parietal lobe; command scores related most closely with the results of tests reflecting verbal proficiency and with cortical metabolism in the left inferior hemisphere, especially frontally. Apraxia to command and imitation may thus reflect neuronal dysfunction in distinct cerebral regions in patients with Alzheimer's disease.