Salmonellosis outcomes differ substantially by serotype
Salmonellosis outcomes differ substantially by serotype
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DOI：
10.1086/588823
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发表时间：
2008-07-01
影响因子：
6.4
通讯作者：
Angulo, Frederick J.
中科院分区：
文献类型：
--
作者：
Jones, Timothy F.;Ingram, L. Amanda;Angulo, Frederick J.
背景大多数人类感染是由1种沙门氏菌中密切相关的血清型引起的。关于常见血清型之间疾病严重程度差异的数据很少。我们检查了1996-2006年期间FoodNet各州所有沙门氏菌感染病例的数据。资料包括血清型、标本来源、住院情况和结果。在46 639例病例中，确定了687种血清型。总体而言，41，624株分离株（89%）来自粪便标本，2524株（5%）来自血液，1669株（4%）来自尿液; 10，393例（22%）病例需要住院治疗，219例（0.5%）发生死亡。S.纽波特（0.3%）显著低于鼠伤寒（0.6%）;都柏林（3.0%）较高。在侵袭性疾病方面，13种血清型的比例显著高于鼠伤寒（6%），包括肠炎（7%）、海德堡（13%）、猪霍乱（57%）和都柏林（64%）; 13种血清型的侵袭性显著较低。十二种血清型，包括肠杆菌（21%）和Javiana（21%），比鼠伤寒（24%）更不容易导致住院;猪霍乱（60%）明显更容易。沙门氏菌血清型在遗传上密切相关，但它们的致病潜力显著不同。了解这一机制可能是更全面地了解肠道细菌感染侵袭性的关键。
Background. Most human infections are caused by closely related serotypes within 1 species of Salmonella. Few data are available on differences in severity of disease among common serotypes.Methods. We examined data from all cases of Salmonella infection in FoodNet states during 1996-2006. Data included serotype, specimen source, hospitalization, and outcome.Results. Among 46,639 cases, 687 serotypes were identified. Overall, 41,624 isolates (89%) were from stool specimens, 2524 (5%) were from blood, and 1669 (4%) were from urine; 10,393 (22%) cases required hospitalization, and death occurred in 219 (0.5%). The case fatality rate for S. Newport (0.3%) was significantly lower than for Typhimurium (0.6%); Dublin (3.0%) was higher. With respect to invasive disease, 13 serotypes had a significantly higher proportion than Typhimurium (6%), including Enteritidis (7%), Heidelberg (13%), Choleraesuis (57%), and Dublin (64%); 13 serotypes were significantly less likely to be invasive. Twelve serotypes, including Enteritidis (21%) and Javiana (21%), were less likely to cause hospitalization than Typhimurium (24%); Choleraesuis (60%) was significantly more so.Conclusions. Salmonella serotypes are closely related genetically yet differ significantly in their pathogenic potentials. Understanding the mechanisms responsible for this may be key to a more general understanding of the invasiveness of intestinal bacterial infections.