Socially induced plasticity in sensorimotor gating in the African cichlid fish Astatotilapia burtoni
Socially induced plasticity in sensorimotor gating in the African cichlid fish Astatotilapia burtoni
复制标题
非洲丽鱼科鱼 Astatotilapia burtoni 感觉运动门控的社会诱导可塑性
DOI：
10.1016/j.bbr.2017.05.049
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发表时间：
2017
影响因子：
2.7
通讯作者：
Preuss, Thomas
中科院分区：
文献类型：
--
作者：
Neumeister, Heike;Adelman, Mila;Gallagher, William;Gou, Jiangtao;Merrins, Karin;Perkowski, Melissa;Shih, Stephanie;Terranova, Beth;Preuss, Thomas
前脉冲抑制（PPI）、社交失败和社交退缩的缺陷是几种神经系统和神经精神疾病的标志性特征。然而，社会环境与生产者价格指数之间的联系，即，社会失败在推动PPI可塑性方面可能扮演的角色还远未明确。在这里，我们探讨了这些问题，在非洲慈鲷鱼Astatotilapia burtoni，男性存在两个不同的，但可逆的表型。在鱼类群落中，DOM表现出频繁的侵略性和领土行为，威胁和攻击潜艇，这要么参与战斗和逃跑，或完全避免与DOM的互动。社会表型的选择使用的主导和顺从行为的焦点观察。听觉PPI测试显示，在ISI 50 ms的前脉冲/脉冲刺激间间期时，与DOM相比，SUB的PPI显著降低。有趣的是，进一步的分析显示，SUBs的PPI下降是由社交互动性低的男性驱动的。测试男性之前和之后的社会转型显示上升和下降的男性，分别增加和减少PPI。在开放领域的范例中，与DOM相比，SUB也显示出更高水平的贴壁（趋触性）和冻结，即，焦虑相关行为的增加。总之，这些结果表明A中不同但可逆的行为PPI表型。burtonimales，社会失败驱动PPI可塑性。PPI赤字很容易通过状态改变而逆转的事实意味着PPI可塑性可能反映了对社会环境中挑战的适应性反应。
Deficits in prepulse inhibition (PPI), social defeat and social withdrawal are hallmark features of several neurological and neuropsychiatric disorders. However, the link between social environment and PPI i.e., the possible role of social defeat in driving PPI plasticity, is far from clear. Here we explored these questions in the African cichlid fishAstatotilapia burtoni, where males exist as two distinct yet reversible phenotypes. In fish communities, DOMs exhibit frequent aggressive and territorial behaviors, threatening and attacking SUBs, which respond either by engaging in fights and fleeing, or by avoiding interaction with DOMs altogether. Social phenotypes were selected using focal observations of dominant and submissive behaviors. Tests of auditory PPI showed markedly decreased PPI in SUBs as compared to DOMs at prepulse/pulse interstimulus interval of ISI 50 ms. Interestingly, further analysis showed the PPI reduction in SUBs was driven by males with low social interactivity. Testing males before and after social transitions revealed increasing and decreasing PPI in ascending and descending males, respectively. In an open field paradigm, SUBs also showed higher levels of wall hugging (thigmotaxis) and freezing when compared to DOMs i.e., an increase in anxiety-related behavior. Together the results suggest distinct yet reversible behavioral PPI phenotypes inA. burtonimales, and that social defeat drives PPI plasticity. The fact that PPI deficits are readily reversible by status change implies PPI plasticity may reflect an adaptive response to challenges in the social environment.