The Disease Burden and Clinical Characteristics of Inflammatory Bowel Disease in the Chinese Population: A Systematic Review and Meta-Analysis.
The Disease Burden and Clinical Characteristics of Inflammatory Bowel Disease in the Chinese Population: A Systematic Review and Meta-Analysis.
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中国人群炎症性肠病的疾病负担和临床特征：系统评价和荟萃分析
DOI：
10.3390/ijerph14030238
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发表时间：
2017-02-28
影响因子：
--
通讯作者：
Yu Z
中科院分区：
文献类型：
--
作者：
Li X;Song P;Li J;Tao Y;Li G;Li X;Yu Z
据报道，炎症性肠病（IBD）的发病率在全球范围内呈上升趋势;然而，针对中国的报告很少。本研究旨在概述中国人群中IBD的疾病负担和临床特征。我们检索了Medline、EMBASE和另外两个中文数据库。同时进行了文献综述和数据提取。对克罗恩病（CD）和溃疡性结肠炎（UC）的总发病率进行Meta分析。计算临床表型和分类的构成比及其95%CI。文献综述包括47篇出版物。IBD的汇总发生率为1.74（95% CI：1.08; 2.40）/100，000人年，CD和UC的相应发生率分别为0.40（95% CI：0.23; 0.57）和1.18（95% CI：0.81; 1.56）/100，000人年。性别分布分析表明，CD（性别比：1.64; 95% CI：1.47-1.84）和UC（性别比：1.29; 95% CI：1.21-1.38）均以男性为主。使用来自2283例CD病例和17，958例UC病例的数据总结了临床特征;其中大多数CD患者的诊断年龄在17-40岁之间，具有非狭窄和非穿透性疾病，疾病部位多样，肠外表现较少。UC病例的特点是疾病诊断较晚、病程较重、节段性病变较多、肠外表现较少。我们的研究提供了IBD的估计疾病负担，并证明了中国人群的独特临床特征。需要进行大规模的基于人群的研究来进一步评估这些发现。
The temporal trend of inflammatory bowel disease (IBD) incidence is reported to be increasing in worldwide regions; however, reports focusing on China are sparse. The aim of this study was to provide an overview of the disease burden and clinical features of IBD in the Chinese population. We searched Medline, EMBASE, and another two Chinese databases. A parallel literature review and data extraction were conducted. Meta-analysis was performed to estimate the summary incidence rate of Crohn’s disease (CD) and ulcerative colitis (UC). The constituent ratios with 95% CI were calculated for clinical phenotypes and classifications. The literature review included 47 publications. The summary incidence rate of IBD was 1.74 (95% CI: 1.08; 2.40) per 100,000 person years, and the corresponding incidence rates of CD and UC were 0.40 (95% CI: 0.23; 0.57) and 1.18 (95% CI: 0.81; 1.56) per 100,000 person years, respectively. The sex distribution analysis indicated a male predominance in both CD (sex ratio: 1.64; 95% CI: 1.47–1.84) and UC (sex ratio: 1.29; 95% CI: 1.21–1.38). The clinical characteristics were summarized using data from 2283 CD cases and 17,958 UC cases; in which the majority of CD patients were diagnosed between 17–40 years of age, with non-stricturing and non-penetrating disease, varied disease locations, and less extra-intestinal manifestation. UC cases were featured with later disease diagnosis, a more severe disease course, more segmental lesions, and less extra-intestinal manifestations. Our study provided an estimated disease burden of IBD and demonstrated distinct clinical features in the Chinese population. Large-scale population-based studies are needed to further evaluate these findings.