Increased hydrogen peroxide generation by neutrophils from patients with acne inflammation
Increased hydrogen peroxide generation by neutrophils from patients with acne inflammation
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DOI：
10.1046/j.1365-4362.2003.01540.x
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发表时间：
2003-05-01
影响因子：
3.6
通讯作者：
Hattori, K
中科院分区：
文献类型：
--
作者：
Akamatsu, H;Horio, T;Hattori, K
研究背景中性粒细胞产生的活性氧与多种炎症性皮肤病的发病机制密切相关。本研究的目的是探讨中性粒细胞产生的活性氧在痤疮inflammatory.Methods介导的细菌吞噬刺激，调理素活性介导的，可能的作用施加到全血，结果痤疮炎症患者表现出显着增加的水平，由中性粒细胞产生的过氧化氢相比，痤疮粉刺，健康对照痤疮粉刺患者和健康对照组中性粒细胞产生的过氧化氢水平无显著差异。此外，痤疮炎症治疗的患者口服盐酸米诺环素，一种药物，抑制过氧化氢产生的中性粒细胞，表现出显着减少中性粒细胞产生过氧化氢的能力，按照减少炎症活动的痤疮lesions.Conclusions本研究似乎表明，痤疮炎症介导的部分过氧化氢产生的中性粒细胞。
Background Reactive oxygen species generated by neutrophils are closely correlated with the pathogenesis of a variety of inflammatory skin diseases. The aim of this study was to investigate the possible role of reactive oxygen species generated by neutrophils in the mediation of acne inflammation.Methods Bacterial phagocytotic stimuli, mediated by opsonin activity, were applied to whole blood, and neutrophil hydrogen peroxide production was measured.Results Patients with acne inflammation showed a significantly increased level of hydrogen peroxide produced by neutrophils compared to patients with acne comedones and healthy controls. There were no marked differences in the level of hydrogen peroxide produced by neutrophils between patients with acne comedones and healthy controls. In addition, patients with acne inflammation treated by oral administration of minocycline hydrochloride, a drug that inhibits hydrogen peroxide generation by neutrophils, showed a significant decrease in the ability of neutrophils to produce hydrogen peroxide in accordance with a decrease in the inflammatory activity of acne lesions.Conclusions The present study seems to suggest that acne inflammation is mediated in part by hydrogen peroxide generation by neutrophils.