Enzymatic approach to unnatural glycosides with diverse aglycon scaffolds using glycosyltransferase VinC
Enzymatic approach to unnatural glycosides with diverse aglycon scaffolds using glycosyltransferase VinC
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DOI：
10.1021/ja042848j
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发表时间：
2005-05-04
影响因子：
15
通讯作者：
Kakinuma, K
中科院分区：
文献类型：
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作者：
Minami, A;Uchida, R;Kakinuma, K
探索了糖基转移酶VinC用于使用dTDP-维西尼沙胺和结构上不相关的非天然糖苷配基构建糖苷文库，并且成功构建了新的非天然维西尼沙胺。通过建模研究提出了VinC识别糖苷配基的结构要素，并通过设计糖苷配基后成功转糖基化来证实。
Glycosyltransferase VinC was explored for a construction of glycoside libraries using dTDP-vicenisamine and structurally unrelated unnatural aglycons, and new unnatural vicenisaminides were successfully constructed. Structural elements of aglycon recognition by VinC were proposed by modeling studies and were confirmed by the success of transglycosylation upon a designed aglycon.