Signaling by cGAS-STING in Neurodegeneration, Neuroinflammation, and Aging.
Signaling by cGAS-STING in Neurodegeneration, Neuroinflammation, and Aging.
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环鸟苷酸-腺苷酸合成酶（cGAS）-干扰素基因刺激因子（STING）在神经退行性疾病、神经炎症和衰老中的信号传导
DOI：
10.1016/j.tins.2020.10.008
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发表时间：
2021-03
影响因子：
15.9
通讯作者：
Bohr VA
中科院分区：
文献类型：
--
作者：
Paul BD;Snyder SH;Bohr VA
对外源或错位核酸的识别是免疫系统检测病原体的主要方式之一。当细胞质DNA被感知到时，会通过cGAS - STING通路传递信号：这涉及环鸟苷酸 - 腺苷酸（cGMP - AMP）合酶（cGAS）的激活以及环二核苷酸cGAMP的产生，随后诱导干扰素基因刺激因子（STING）。cGAS - STING通路对病毒、细菌和自身DNA都有反应。虽然它通常介导免疫监视且常常具有神经保护作用，但该系统的过度激活可能是有害的。这与衰老以及年龄相关的神经系统疾病有关，在这些疾病中，神经炎症会促进疾病进展。本综述重点关注衰老、神经退行性变和神经炎症中的cGAS - STING信号传导以及治疗意义。
Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is relayed via the cGAS-STING pathway: this involves the activation of the cyclic guanosine monophosphate-adenosine monophosphate (cGMP-AMP) synthase (cGAS) and generation of the cyclic dinucleotide, cGAMP, followed by the induction of stimulator of interferon genes (STING). The cGAS-STING pathway responds to viral, bacterial and self-DNA. Whereas it generally mediates immune surveillance and is often neuroprotective, excessive engagement of the system can be deleterious. This is relevant in ageing, and age-related neurological diseases, where neuroinflammation contributes to disease progression. This review focuses on cGAS-STING signaling in aging, neurodegeneration and neuroinflammation, and on therapeutic implications.
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影响因子：
21.3
作者：
Glück S;Guey B;Gulen MF;Wolter K;Kang TW;Schmacke NA;Bridgeman A;Rehwinkel J;Zender L;Ablasser A
通讯作者：
Ablasser A
影响因子：
2
作者：
Crow, Yanick J.;Chase, Diana S.;Schmidt, Johanna Lowenstein;Szynkiewicz, Marcin;Forte, Gabriella M. A.;Gornall, Hannah L.;Oojageer, Anthony;Anderson, Beverley;Pizzino, Amy;Helman, Guy;Abdel-Hamid, Mohamed S.;Abdel-Salam, Ghada M.;Ackroyd, Sam;Aeby, Alec;Agosta, Guillermo;Albin, Catherine;Allon-Shalev, Stavit;Arellano, Montse;Ariaudo, Giada;Aswani, Vijay;Babul-Hirji, Riyana;Baildam, Eileen M.;Bahi-Buisson, Nadia;Bailey, Kathryn M.;Barnerias, Christine;Barth, Magalie;Battini, Roberta;Beresford, Michael W.;Bernard, Genevieve;Bianchi, Marika;de Villemeur, Thierry Billette;Blair, Edward M.;Bloom, Miriam;Burlina, Alberto B.;Carpanelli, Maria Luisa;Carvalho, Daniel R.;Castro-Gago, Manuel;Cavallini, Anna;Cereda, Cristina;Chandler, Kate E.;Chitayat, David A.;Collins, Abigail E.;Sierra Corcoles, Concepcion;Cordeiro, Nuno J. V.;Crichiutti, Giovanni;Dabydeen, Lyvia;Dale, Russell C.;D'Arrigo, Stefano;De Goede, Christian G. E. L.;De Laet, Corinne;De Waele, Liesbeth M. H.;Denzler, Ines;Desguerre, Isabelle;Devriendt, Koenraad;Di Rocco, Maja;Fahey, Michael C.;Fazzi, Elisa;Ferrie, Colin D.;Figueiredo, Antonio;Gener, Blanca;Goizet, Cyril;Gowrinathan, Nirmala R.;Gowrishankar, Kalpana;Hanrahan, Donncha;Isidor, Bertrand;Kara, Lent;Khan, Nasaim;King, Mary D.;Kirk, Edwin P.;Kumar, Ram;Lagae, Lieven;Landrieu, Pierre;Lauffer, Heinz;Laugel, Vincent;La Piana, Roberta;Lim, Ming J.;Lin, Jean-Pierre S. -M.;Linnankivi, Tarja;Mackay, Mark T.;Marom, Daphna R.;Lourenco, Charles Marques;McKee, Shane A.;Moroni, Isabella;Morton, Jenny E. V.;Moutard, Marie-Laure;Murray, Kevin;Nabbout, Rima;Nampoothiri, Sheela;Nunez-Enamorado, Noemi;Oades, Patrick J.;Olivieri, Ivana;Ostergaard, John R.;Perez-Duenas, Belen;Prendiville, Julie S.;Ramesh, Venkateswaran;Rasmussen, Magnhild;Regal, Luc;Ricci, Federica;Rio, Marlene;Rodriguez, Diana;Roubertie, Agathe;Salvatici, Elisabetta;Segers, Karin A.;Sinha, Gyanranjan P.;Soler, Doriette;Spiegel, Ronen;Stoedberg, Tommy I.;Straussberg, Rachel;Swoboda, Kathryn J.;Suri, Mohnish;Tacke, Uta;Tan, Tiong Y.;Naude, Johann te Water;Teik, Keng Wee;Thomas, Maya Mary;Till, Marianne;Tonduti, Davide;Valente, Enza Maria;Van Coster, Rudy Noel;van der Knaap, Marjo S.;Vassallo, Grace;Vijzelaar, Raymon;Vogt, Julie;Wallace, Geoffrey B.;Wassmer, Evangeline;Webb, Hannah J.;Whitehouse, William P.;Whitney, Robyn N.;Zaki, Maha S.;Zuberi, Sameer M.;Livingston, John H.;Rozenberg, Flore;Lebon, Pierre;Vanderver, Adeline;Orcesi, Simona;Rice, Gillian I.
通讯作者：
Rice, Gillian I.
DOI：
10.1126/science.1252945
发表时间：
2014-10-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Baruch K;Deczkowska A;David E;Castellano JM;Miller O;Kertser A;Berkutzki T;Barnett-Itzhaki Z;Bezalel D;Wyss-Coray T;Amit I;Schwartz M
通讯作者：
Schwartz M
影响因子：
64.8
作者：
Coquel, Flavie;Silva, Maria-Joao;Pasero, Philippe
通讯作者：
Pasero, Philippe
影响因子：
64.8
作者：
Andreeva, Liudmila;Hiller, Bjoern;Hopfner, Karl-Peter
通讯作者：
Hopfner, Karl-Peter