ELECTROPHYSIOLOGY OF HIPPOCAMPAL NEURONS .1. SEQUENTIAL INVASION AND SYNAPTIC ORGANIZATION
ELECTROPHYSIOLOGY OF HIPPOCAMPAL NEURONS .1. SEQUENTIAL INVASION AND SYNAPTIC ORGANIZATION
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DOI：
10.1152/jn.1961.24.3.225
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发表时间：
1961-01-01
影响因子：
2.5
通讯作者：
BRINLEY, FJ
中科院分区：
文献类型：
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作者：
KANDEL, ER;SPENCER, WA;BRINLEY, FJ
从麻醉猫的海马神经元中获得细胞内记录，以测试来自脊髓运动神经元研究的哺乳动物中枢神经元在皮质非运动细胞中的当前模型。根据细胞对逆向刺激的反应，将被刺穿的细胞分为已鉴定的锥体细胞和未鉴定的细胞。这两个群体具有相似的属性。海马神经元放电的上升相有一个台阶，表明A区先于B区放电，表明海马神经元的顺序侵入。这一步骤可以用顺向和直接以及逆向激活模式来证明。突触兴奋伴随去极化，抑制伴随超极化。后者是从一个hyper-到一个去极化突触后电位的KCl电极的Cl-的扩散反转。刺激逆向通路激活一个强大的抑制性复发轴突侧支系统。所选择的比较点与运动神经元模型完全兼容。
Intracellular recordings have been obtained from hippocampal neurons of anesthetized cats for the purpose of testing the current model of the mammalian central neuron, derived from studies of the spinal motoneuron, in a cortical nonmotor cell. On the basis of their response to antidromic stimulation the impaled cells were classified as identified pyramidal and unidentified cells. Both groups have similar properties. The rising phase of the hippocampal neuron spike has a step indicating sequential invasion with the A area firing before the B area. This step can be demonstrated with ortho-dromic and direct as well as with antidromic modes of activation. Synap-tic excitation occurs with depolarization and inhibition with hyperpolari-zation. The latter is inverted from a hyper- to a depolarizing postsyn-aptic potential by the diffusion of Cl- from KCl electrodes. Stimulation of the antidromic pathway activates a powerful system of inhibitory recurrent axon collaterals. The selected points of comparison are fully compatible with the motoneuron model.